Paired box protein Pax-6, also known as aniridia type II protein (AN2) or oculorhombin, is a protein that in humans is encoded by the PAX6 gene. [5] Fruitflies lacking the PAX6 gene have no eyes. PAX6 is a member of the Pax gene family which is responsible for carrying the genetic information that will encode the Pax-6 protein.

2024年12月25日 · PAX6 (Paired Box 6) is a Protein Coding gene. Diseases associated with PAX6 include Coloboma Of Optic Nerve and Foveal Hypoplasia 1. Among its related pathways are Incretin synthesis, secretion, and inactivation and Regulation of beta-cell development.

2025年2月8日 · Title: PAX6 promotes neuroendocrine phenotypes of prostate cancer via enhancing MET/STAT5A-mediated chromatin accessibility. A positive feedback inhibition of isocitrate dehydrogenase 3beta on paired-box gene 6 promotes Alzheimer-like pathology.

The PAX6 gene belongs to a family of genes that play a critical role in the formation of tissues and organs during embryonic development. The members of the PAX gene family are also important for maintaining the normal function of certain cells after birth.

PAX6 is a key transcription factor involved in brain development and has crucial roles in eye formation and brain development. It regulates the expression of many genes during corticogenesis and is responsible for balancing the proliferation and differentiation of neural stem/progenitor cells.

Pax6 is a sequence-specific DNA binding transcription factor that positively and negatively regulates transcription and is expressed in multiple cell types in the developing and adult central nervous system (CNS). As indicated by the morphological ...

Interactions between orthologous genes from the Pax and Six families have been identified in Drosophila and vertebrate species, and we examined the control of Pax6 and Six3 gene expression in the developing mouse lens.

2012年9月1日 · The transcription factor Pax6 has been shown to play a key role in each of these processes. Pax6 is required for initiation of developmental pathways, patterning of epithelial tissues, activation of tissue-specific genes and interaction with other regulatory pathways.

2020年11月30日 · PAX6 ; Function of gene/protein: Protein: Paired box 6; Regulates other genes by binding to specific DNA regions (transcription factor) During embryonic development, PAX6 activates genes involved in eye, central nervous system and pancreas development

2016年2月9日 · These findings demonstrate new aspects of the gene regulatory circuitry of Pax6, revealing how it functions to control neuronal development at multiple levels to ensure unidirectionality and...