Dec 25, 2024 · PARP14 (Poly (ADP-Ribose) Polymerase Family Member 14) is a Protein Coding gene. Diseases associated with PARP14 include Diphtheria and Tfe3-Rearranged Renal Cell Carcinoma. Among its related pathways are Translation of Structural Proteins and …

Sep 26, 2023 · We observe upregulation of poly-ADP ribosyl polymerase 14 (PARP14) in chronic IFNγ-treated cancer cell models, in patient melanoma with elevated IFNG expression, and in melanoma cell cultures...

Sep 13, 2023 · PARP14 is a mono–ADP-ribosyl transferase involved in the control of immunity, transcription, and DNA replication stress management. However, little is known about the ADP-ribosylation activity of PARP14, including its substrate specificity or how PARP14-dependent ADP-ribosylation is reversed.

parp14缺乏会延迟b细胞淋巴瘤的发生并阻止myc驱动的b细胞成熟。 PARP9，PARP14和PARP15都包含一个与ADP-核糖或聚（ADP-核糖）结合的宏结构域。 PARP12和PARP13均具有抗病毒活性 83 和PARP13已显示通过其氨基末端CCCH锌指基序（zf-CCCH）结合并破坏病毒mRNA的稳定性-PARP12也可能 ...

PARP14 can cleave one NAD + molecule into one ADP ribose and nicotinamide, and then transfer the mono (ADP-ribose) unit onto target proteins. Based on this particular biochemical reaction in cells, PARP14 has been regarded as an arrestive drug target for anticancer and anti-inflammatory therapy.

Poly (ADP-ribosyl)ation is an immediate DNA damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP14 belongs to the superfamily of enzymes that perform this modification (Ame et al., 2004 [PubMed 15273990]). ^ "Human PubMed Reference:".

Feb 9, 2025 · PARP14 Contributes to the Development of the Tumor-Associated Macrophage Phenotype. Targeting PARP14 with lomitapide suppresses drug resistance through the activation of DRP1-induced mitophagy in multiple myeloma. PARP14 correlates with GBM proliferation and poor prognosis by elevating expression of SAMD/SAMD9L.

Sep 15, 2023 · We show that PARP14 is a dual-function enzyme with both ADP-ribosyl transferase and hydrolase activity acting on both protein and nucleic acid substrates. In particular, we show that the PARP14 macrodomain 1 is an active ADP-ribosyl hydrolase. We also demonstrate hydrolytic activity for the first macrodomain of PARP9.

PARP14/BAL2 is a large multidomain enzyme involved in signaling pathways with relevance to cancer, inflammation, and infection. Inhibition of its mono-ADP-ribosylating PARP homology domain and its three ADP-ribosyl binding macro domains has been regarded as a potential means of therapeutic intervention.

Ubiquitous expression in spleen (RPKM 17.4), appendix (RPKM 15.1) and 24 other tissues. 该基因编码聚 (ADP-核糖) 聚合酶 (PARP) 蛋白家族的成员。 编码的抗凋亡蛋白可以调节有氧糖酵解并促进癌细胞的存活。 已在多种肿瘤类型中报道了该基因表达增加。 [RefSeq 提供，2016 年 7 月] This gene encodes a member of the poly (ADP-ribose) polymerase (PARP) protein family.