2024年12月25日 · PARK7 (Parkinsonism Associated Deglycase) is a Protein Coding gene. Diseases associated with PARK7 include Parkinson Disease 7, Autosomal Recessive Early-Onset and Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1. Among its related pathways are Selective autophagy and Metabolism of proteins.

The PARK7 gene provides instructions for making the DJ-1 protein. This protein is found in many tissues and organs, including the brain. Studies indicate that the DJ-1 protein has several functions, although none are fully understood. One of the protein's functions may be to help protect cells, particularly brain cells, from oxidative stress.

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Mutations in the PD-associated gene PARK7 alter the structure and function of the encoded protein DJ-1, and the resulting autosomal recessively inherited disease increases the risk of developing PD. DJ-1 was first discovered in 1997 as an oncogene and was associated with early-onset PD in 2003.

PARK7 (DJ-1) is an evolutionary conserved gene that is abundantly expressed in brain and other tissues, and encodes a 189 amino acid protein. Loss-of-function, recessive PARK7 mutations are a rare cause of early-onset human parkinsonism. The normal function of the PARK7 protein and how its defect causes neurodegeneration remain unclear.

PARK7 activates various intracellular signaling pathways that have been implicated in the induction of tumor progression, which subsequently enhances tumor initiation, continued proliferation, metastasis, recurrence, and resistance to chemotherapy.

2022年1月25日 · Here we report that PARK7, an enzyme mutated in hereditary Parkinson's disease, prevents damage of proteins and metabolites caused by a metabolite of glycolysis. We found that the glycolytic metabolite 1,3-bisphosphoglycerate (1,3-BPG) spontaneously forms a novel reactive intermediate that avidly reacts with amino groups.

DJ-1, encoded in a causative gene of familial Parkinson's disease (PARK7), has multiple functions: it works as an antioxidant, in transcriptional regulation, as a molecular chaperone and in protein degradation.

2025年2月9日 · PARK7/DJ-1 inhibition decreases invasion and proliferation of uveal melanoma cells. DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy. DJ-1 activates the AMPK/mTOR pathway by binding RACK1 to induce autophagy and protect the myocardium from ischemia/hypoxia injury.