PTGS2 (COX-2), converts arachidonic acid (AA) to prostaglandin endoperoxide H2. PTGSs are targets for NSAIDs and PTGS2 (COX-2) specific inhibitors called coxibs. PTGS-2 is a …

Dec 25, 2024 · PTGS2 is the principal isozyme responsible for production of inflammatory prostaglandins. New generation PTGSs inhibitors strive to be selective for PTGS2, to avoid …

Herein, we review the main effects of this molecular pathway in a tissue-specific manner, with a special emphasis on beta cell mass protection/destruction and its potential role in the …

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are …

Very important pharmacogene: PTGS2. This PharmGKB summary briefly discusses the PTGS2 gene and current understanding of its function, structure, regulation, and pharmacogenomic …

COX-2 is the product of prostaglandin-endoperoxide synthase 2 (PTGS2) gene expression. COX-2 dysregulation can cause angiogenesis, differentiation, and promotion of cancer and its …

Sep 14, 2016 · Gene target information for PTGS2 - prostaglandin-endoperoxide synthase 2 (human). Find diseases associated with this biological target and compounds tested against it …

Mar 12, 2025 · PTGS2, a key enzyme in PGE2 synthesis, is considered one of the key factors regulating ferroptosis . The induction of disease by PTGS2 through mediating ferroptosis has …

Aug 6, 2023 · The inducible Prostaglandin Endoperoxide Synthase 2/Cyclooxygenase 2 (PTGS2/COX2) plays an important role in pathologies associated with inflammatory signaling. …

May 22, 2024 · Prostaglandin-endoperoxide synthase 2 (PTGS2, also called COX2) acts as an oncogenic driver in CRC. Here, we explored the upstream transcription factors (TFs) …

Metabolizes 2-arachidonoyl glycerol yielding the glyceryl ester of PGH2, a process that can contribute to pain response (By similarity). Generates lipid mediators from n-3 and n-6 …

Jan 5, 2025 · Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a …

The PTGS2 gene codes for the cyclooxygenase-2 (COX-2) enzyme that catalyzes the committed step in prostaglandin (PG) synthesis. Various in-vivo and in-vitro data suggest that …

May 1, 2024 · PTGS2 (encode COX2) is related to inflammatory pathway and immune cell infiltration. COX2 inhibitor celecoxib suppressed mast cell degranulation and allergic reactions. …

Metabolizes 2-arachidonoyl glycerol yielding the glyceryl ester of PGH2, a process that can contribute to pain response (PubMed:22942274). Generates lipid mediators from n-3 and n-6 …

Feb 8, 2025 · PTGS2: A potential immune regulator and therapeutic target for chronic spontaneous urticaria. Abnormal Microglial Density and Morphology in the Brain of …

Nov 29, 2024 · LTA stimulation significantly increases ER stress and apoptosis-related factors in MAC-T. Further analysis suggests that the increase in ER stress may be associated with …

Sep 1, 2023 · Various in-vivo and in-vitro data suggest that prostaglandin E2 mediates as a signaling molecule for activating the VEGF signaling pathway (VSP), forming an association …

Dec 19, 2023 · PTGS2 is the human gene encoding cyclooxygenase 2, which is a key enzyme mediating inflammation in vivo. It is induced by a variety of factors, such as cytokines, growth …

The prostaglandin-endoperoxide synthase 2 (PTGS2), also known as cyclooxygenase-2 (COX-2), is an enzyme encoded by the PTGS2 gene. It plays a role in the conversion of arachidonic …