2012年3月1日 · PRSS1-related hereditary pancreatitis (HP) is characterized by episodes of acute pancreatitis (AP) and recurrent acute pancreatitis (RAP: >1 episode of AP), with frequent progression to chronic pancreatitis (CP).

The PRSS1 gene provides instructions for making an enzyme called cationic trypsinogen. This enzyme is a serine peptidase, which is a type of enzyme that cuts (cleaves) other proteins into smaller pieces. Cationic trypsinogen is produced in the …

Trypsin-1, also known as cationic trypsinogen, is a protein that in humans is encoded by the PRSS1 gene. Trypsin-1 is the main isoform of trypsinogen secreted by pancreas, the others are trypsin-2 (anionic trypsinogen), and trypsin-3 (meso-trypsinogen).

2024年12月25日 · PRSS1 (Serine Protease 1) is a Protein Coding gene. Diseases associated with PRSS1 include Pancreatitis, Hereditary and Hereditary Chronic Pancreatitis. Among its related pathways are Metabolism of water-soluble vitamins and …

Mutations in the PRSS1 gene cause most cases of hereditary pancreatitis. The PRSS1 gene provides instructions for making an enzyme called cationic trypsinogen. This enzyme is produced in the pancreas and helps with the digestion of food.

Variations in the serine protease 1 (PRSS1) gene encoding human cationic trypsinogen have been conclusively associated with autosomal dominant hereditary pancreatitis and sporadic nonalcoholic chronic pancreatitis.

2025年2月9日 · Title: Silencing PRSS1 suppresses the growth and proliferation of gastric carcinoma cells via the ERK pathway. Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis.

2019年4月25日 · Clinical characteristics: PRSS1 -related hereditary pancreatitis (HP) is characterized by episodes of acute pancreatitis (AP) and recurrent acute pancreatitis (RAP: >1 episode of AP), with frequent progression to chronic pancreatitis (CP).

Human pancreatic juice contains 3 isoforms of trypsinogen. On the basis of their relative electrophoretic mobility, these are commonly referred to as cationic trypsinogen (PRSS1), anionic trypsinogen (PRSS2; 601564), and mesotrypsinogen (PRSS3; 613578).

2012年10月29日 · Clinical resource with information about PRSS1, Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis., Hereditary pancreatitis, and available tests.