PRDM1/BLIMP-1 is a master transcription factor regulating downstream cytokines. It is activated by TLRs and IRF-4, and is crucial in T cell, B cell, and myeloid lineage cell differentiations.

2024年12月25日 · PRDM1 (PR/SET Domain 1) is a Protein Coding gene. Diseases associated with PRDM1 include Myeloma, Multiple and Plasmablastic Lymphoma. Among its related pathways are Gene expression (Transcription) and Regulation of TP53 Activity.

2022年12月12日 · Herein, we identify that tumoral Prdm1 overexpression inhibits cell growth in immune-deficient mouse models. Further, tumoral Prdm1 overexpression upregulates PD-L1 levels, dampening anti-tumor...

PRDM1 and PRDM2, initially identified as Blimp-1 (B lymphocyte-induced maturation protein-1) and RIZ (Retinoblastoma interacting zinc finger protein) respectively, have two promoters that encode for a PR-plus and a PR-minus isoform.

The gene encoding the human BLIMP1, prdm1, is located on chromosome 6q21, a locus frequently deleted in lymphoid tumors. BLIMP1 is able to silence its target genes in a context-dependent manner through different mechanisms.

2022年4月7日 · PRDM1 disruption promoted the expansion of less differentiated memory CAR-T cells in vivo, which enhanced T-cell persistence and improved therapeutic efficacy in multiple tumor models. Mechanistically, PRDM1-ablated T cells displayed enhanced chromatin accessibility of the genes that regulate memory formation, thereby leading to the acquisition ...

2020年12月15日 · Background: PR domain zinc finger protein 1 (PRDM1) is a regulator of both B cell and T cell differentiation and plays a critical role in immunosuppression. Its role in tumor immunity and correlation with drug response remain unknown.

PRDM1 (BLIMP1), a master transcriptional regulator with a PR/SET domain that binds to specific DNA targets via its zinc fingers domains (Morgan et al., 2012), controls DNA binding, nuclear import and recruitment of histone modifying enzymes (Bikoff et al., 2009).

2020年6月3日 · Here we describe Blimp1 expression and functional requirements within maternal uterine tissues during pregnancy. Expression is robustly up-regulated at early post-implantation stages in the...

2025年2月8日 · PRDM1 levels are associated with the clinical diseases of chronic HBV infection. Highly elevated PRDM1 levels are discriminative of hepatocellular carcinoma(HCC) from other clinical diseases and indicative of a poor prognosis of HCC patients.