『珍藏版』Nature系列综述 | 哺乳动物中多梳蛋白抑制复合物基因 …
撰文、编译 | 啾啾椰 基因表达的精确调控是细胞正常发育、行使功能的基础。 基因调控在多种层面上发生，包括DNA 结合转录因子，染色质和组蛋白翻译后修饰等。多梳蛋白抑制复合 …
The roles of Polycomb repressive complexes in mammalian
2021年3月15日 · PcG proteins function on chromatin and can form two distinct complexes with different enzymatic activities: Polycomb repressive complex 1 (PRC1) is a histone ubiquitin …
Polycomb repressive complex 1 - Wikipedia
Polycomb repressive complex 1 (PRC1) is one of the two classes of Polycomb Repressive complexes, the other being PRC2. Polycomb-group proteins play a major role in transcriptional …
Mammalian PRC1 Complexes: Compositional Complexity and Diverse …
2020年11月14日 · The PRC1 complexes are composed in a hierarchical manner in which the catalytic core, RING1A/B, exclusively interacts with one of six Polycomb group RING finger …
Structure and Function of the Polycomb Repressive Complexes PRC1 …
Reddington et al. review the role of the Polycomb Repressive-Deubiquinase (PR-DUB) complex, which antagonizes PRC1 action. H2AK119ub is central to Polycomb-mediated gene silencing …
Modularity of PRC1 composition and chromatin interaction define ...
2024年3月22日 · Through reconstitution and imaging, Niekamp et al. reveal that the Polycomb repressive complex 1 (PRC1) and chromatin act synergistically to form condensates. They …
Live-cell single particle tracking of PRC1 reveals a highly dynamic ...
2021年2月9日 · By quantifying absolute PRC1 complex numbers and integrating genomic information, we estimate maximum target site occupancy and discover that most PRC1 target …
Polycomb complexes PRC1 and their function in hematopoiesis
2017年4月1日 · PcG proteins assemble into two major types of Polycomb repressive complexes (PRCs) endowed with distinct histone-tail-modifying activities. PRC1 complexes are histone …
PRC1 Protein Subcomplexes Architecture: Focus on the Interplay …
The six PCGF proteins (PCGF1-6) define the biochemical identity of Polycomb repressor complex 1 (PRC1) subcomplexes. While structural and functional studies of PRC1 subcomplexes have …
Molecular architecture of polycomb repressive complexes - PMC
The polycomb group (PcG) proteins are a large and diverse family that epigenetically repress the transcription of key developmental genes. They form three broad groups of polycomb …
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