Dec 25, 2024 · PLK3 (Polo Like Kinase 3) is a Protein Coding gene. Diseases associated with PLK3 include Breast Cancer and Ataxia-Telangiectasia. Among its related pathways are Gene expression (Transcription) and Regulation of TP53 Activity.

Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene. [5][6] Cytokine-inducible kinase is a putative serine/threonine kinase. CNK …

Apr 27, 2015 · Plk3 contributes to the control and progression of the cell cycle while acting as a mediator of apoptosis and various types of cellular stress. The aberrant expression of Plk3 was found in...

Oct 26, 2019 · This study suggests that PLK3 inhibits glucose metabolism by targeting HSP90/STAT3/HK2 signaling and PLK3 may serve as a potential therapeutic target in colorectal cancer.

Sep 23, 2002 · Here we show that Plk3 is a stress response protein that becomes phosphorylated following DNA damage or mitotic spindle disruption. Phosphorylation enhances its kinase activity and is...

Plk3 is in a pathway linking ATM, Plk3, Chk2, Cdc25C and Cdc2 in cellular response to DNA damage. Plk3 is a multifunctional protein that associates with multiple complexes and that contributes to response to stress incurred by DNA damage and mitotic spindle disruption, albeit via different pathways.

PLK3 was found lower expressed in lung squamous cell carcinoma than normal sample. Overall, these results in two lung cancer subtypes from TCGA corroborated the findings of PLK1/2/3/4 expression from Oncomine database.

Human Polo-like kinase 3 (Plk3, previously termed Prk or Fnk) is involved in regulation of cell cycle progression through the M phase (B. Ouyang, H. Pan, L. Lu, J. Li, P. Stambrook, B. Li, and W. Dai, J. Biol. Chem. 272:28646-28651, 1997).

Jan 14, 2016 · Plk3 contributes to the control and progression of the cell cycle while acting as a mediator of apoptosis and various types of cellular stress. The aberrant expression of Plk3 was found in different types of tumors.

Polo-like kinase 3 (Plk3) plays an important role in the regulation of cell cycle progression and stress responses. Plk3 also has a tumor-suppressing activity as aging PLK3-null mice develop tumors in multiple organs.