Protein kinase RNA-activated also known as protein kinase R (PKR), interferon-induced, double-stranded RNA-activated protein kinase, or eukaryotic translation initiation factor 2-alpha kinase …

PKR (protein kinase R) is a central component of the interferon antiviral defense pathway. Upon binding dsRNA, PKR undergoes autophosphorylation reactions that activate the kinase. PKR …

Protein kinase R (PKR) is a serine-threonine kinase (551 amino acid long) encoded in humans by the EIF2AK2 gene [located on chromosome 2 (Feng et al., 1992)], which plays a major role in …

We discuss the mechanisms and pathways involved in PKR-induced apoptosis and review the experimental findings that support or do not support PKR involvement as a tumor suppressor, …

Protein kinase R (PKR) is an interferon-induced kinase that plays a key role in the innate immunity response to viral infection (Toth et al., 2006). PKR is induced in a latent form that is activated …

PKR mediates responses via phosphorylation of protein substrates and promotes signal transduction pathways to maintain homeostasis, mediate immune responses, and, upon …

2007年6月1日 · PKR: induction, activation and its role in different cellular pathways. Viral infections provoke induction and secretion of IFN, which then binds to specific cellular …

PKR is constitutively expressed at low level, and its expression is up-regulated by interferon alpha/beta signaling. PKR is mainly localized in the cytoplasm with a small fraction in the …

1999年11月4日 · As a vital component of the cellular antiviral response pathway, PKR is autophosphorylated and activated on binding to dsRNA. This results in inhibition of protein …

2019年1月8日 · Both PKR-dependent apoptosis strategies, either with or without blockade of protein synthesis, serve as anti-viral responses. Consequently, many viruses have developed …

2010年5月13日 · PKR, the prototype of the eIF2α kinases, becomes activated by dimerization, which is greatly facilitated by binding of dsRNA to its regulatory domain [7]. Dimerized PKR …

PKR also has the possibility to activate the nuclear factor κ-B pathway, promoting inflammation and cytokine release. PKR is a ubiquitously expressed serine–threonine protein kinase and is …

Protein Kinase R (PKR) is an interferon regulated gene product that is constitutively expressed in all differentiated cells as an inactive protein monomer. It is an effector molecule of the innate …

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In this study, we investigated whether PKR protein expression is correlated with mRNA levels and also evaluated molecular biomarkers that are associated with PKR, such as phosphorylated …

2020年11月1日 · Double-stranded protein kinase, PKR is a recognized inducer of inflammation, oxidonitrosative stress and apoptosis. PKR activates inflammatory signaling cascade through …

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Double‐stranded (ds) RNA‐dependent protein kinase (PKR) is a ubiquitously expressed serine/threonine protein kinase. It was initially identified as an innate immune antiviral protein …

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Indeed, PKR is involved in TNF-dependent activation of c-Jun N-terminal kinase (JNK), NF-kB and protein kinase B. Meanwhile, knockout of PKR could abrogate the TNF-induced activation …