2023年8月24日 · Phosphatidylinositol 4,5-bisphosphate (PIP2) is an essential lipid involved in metabolic processes. It is integral to the cell membrane of all animal and plant cells and acts as a second...

2020年11月6日 · Phosphoinositides play a crucial role in regulating many cellular functions, such as actin dynamics, signaling, intracellular trafficking, membrane dynamics, and cell-matrix adhesion. Central to this process is phosphatidylinositol bisphosphate (PIP2).

PIP 2 and PIP 3 are constituents of plasma membrane and their precisely regulated abundance changes in response to cell intrinsic and/or extrinsic stimuli. The PIP 2 is primarily formed as a result of sequential phosphorylations at position 4 and position 5 hydroxyl residues of PI by PI 4-kinase (PI4K), and PI phosphate kinase (PIPK), respectively.

2000年3月17日 · Phosphatidylinositol (4,5)-bisphosphate (PIP2) and phosphatidylinositol (3,4,5)-trisphosphate (PIP3) represent less than 1% of membrane phospholipids, yet they function in a remarkable number of crucial cellular processes. These low-abundance polyphosphoinositides direct two major independent signaling cascades.

Phosphatidylinositol 4,5-bisphosphate (PIP2) is a minority phospholipid of the inner leaflet of plasma membranes. Many plasma membrane ion channels and ion transporters require PIP2 to function and can be turned off by signaling pathways that deplete PIP2.

2018年10月15日 · Plasma membrane deformation created by solid structure binding generates phosphatidylinositol 4,5-bisphosphate (PIP2) accumulation at the contact site, which binds the Moesin FERM domain...

2019年9月3日 · Phosphatidylinositol-4,5-bisphosphate (PIP2) is an important signaling lipid in eukaryotic cell plasma membranes, playing an essential role in diverse cellular processes. The headgroup of PIP2 is highly negatively charged, and this lipid displays a high critical micellar concentration compared to housekeeping phospholipid analogs.

Phosphatidylinositol 4,5-bisphosphate (PIP 2), a plasma membrane lipid, is hydrolyzed by G q -protein–coupled receptor (G q PCR) signaling into inositol 1,4,5-trisphosphate and diacylglycerol—extensively studied second messengers with profound regulatory effects in …

2011年8月28日 · Here we present the X-ray crystal structure of a Kir2.2 channel in complex with a short-chain (dioctanoyl) derivative of PIP 2. We found that PIP 2 binds at an interface between the...

2020年11月6日 · In this review, we focus on past and recent exciting results on different molecular mechanisms that regulate cellular functions by binding of specific proteins to PIP2 or by stabilizing phosphoinositide pools in different cellular compartments.