Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.

Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K pathway-targeted therapies have been tested in oncology trials, ...

2017年8月10日 · Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth factor receptors, and elevated PI3K signaling is considered a hallmark of cancer.

The phosphoinositide 3-kinase (PI3K) family is important to nearly all aspects of cell and tissue biology and central to human cancer, diabetes and aging. PI3Ks are spatially regulated and multifunctional, and together, act at nearly all membranes ...

Phosphoinositide 3-kinase (PI3-K) is a dual-specificity kinase with lipid and protein kinase activity. One of its targets is the protein kinase B (PKB or Akt) [89]. The PI3-K/PKB pathway has been shown to deliver an anti-apoptotic signal [90–92], which is negatively regulated by the lipid and protein phosphatase PTEN, a tumour suppressor gene [93].

2012年2月23日 · Phosphoinositide 3-kinases (PI3Ks) generate intracellular lipids that affect a range of cell biological phenomena. They phosphorylate the 3-OH group of inositol membrane lipids to modulate...

Phosphatidylinositol 3-kinase (PI3K) is lipid kinases that regulate diverse cellular processes including proliferation, adhesion, survival, and motility. Dysregulated PI3K pathway signaling occurs in one-third of human tumors.

The PI3K pathway is a key regulatory hub for cell growth, survival, and metabolism. Activation of PI3K is a frequent hallmark of cancer, highlighted by the prevalence of somatic mutations in genes encoding key components of this pathway.

4 天之前 · PI3K inhibitors combined with endocrine therapy have improved outcomes in hormone receptor-positive breast cancer by counteracting resistance mechanisms driven by Akt hyperactivation. Emerging strategies also explore the synergy between PI3K-Akt inhibitors and immune checkpoint blockade, capitalizing on the pathway’s role in tumor immunogenicity.

2019年5月20日 · PI3Ks are a family of lipid kinases that phosphorylate intracellular inositol lipids to regulate signalling and intracellular vesicular traffic. Mammals have eight isoforms of PI3K, divided into...