The enzyme phosphoenolpyruvate carboxykinase (GTP; EC 4.1.1.32) (PEPCK) 2 has the unusual distinction of being very well studied but metabolically misunderstood. As we will document in …

Sep 18, 2015 · Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes a committed and rate-limiting step in hepatic gluconeogenesis, and its activity is tightly regulated to maintain blood …

Phosphoenolpyruvate carboxykinase deficiency is caused by genetic mutations, also known as pathogenic variants. Genetic mutations can be hereditary, when parents pass them down to …

In this third minireview, high-resolution crystal structures of mammalian PEPCK are examined to gain insights into the mechanism of PEPCK catalysis, including the reaction's reversibility and …

Nov 1, 2021 · Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) is a pro-survival, endoplasmic reticulum (ER) stress response gene involved in tumor cell adaptation to nutrient …

Aug 25, 2020 · Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the rate-controlling step of gluconeogenesis, and is thus a central player in glucose homeostasis. In mammals, there …

Dec 8, 2024 · Phosphoenolpyruvate carboxykinase (PEPCK) is an enzyme crucial for gluconeogenesis, the process of generating glucose from non-carbohydrate sources. When …

Dec 30, 2024 · Mitochondrial PEPCK deficiency is a rare genetic disorder that affects the body's ability to produce glucose, leading to severe metabolic issues. This condition stems from …

Background: Phosphoenolpyruvate carboxykinase (PCK) has been almost exclusively recognized as a critical enzyme in gluconeogenesis, especially in the liver and kidney. Accumulating …

Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes a committed and rate-limiting step in hepatic gluconeogenesis, and its activity is tightly regulated to maintain blood glucose levels …