Dec 25, 2024 · PDGFRA (Platelet Derived Growth Factor Receptor Alpha) is a Protein Coding gene. Diseases associated with PDGFRA include Gist-Plus Syndrome and Gastrointestinal Stromal Tumor. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

The PDGFRA gene provides instructions for making a protein called platelet-derived growth factor receptor alpha (PDGFRA), which is part of a family of proteins called receptor tyrosine kinases (RTKs). Learn about this gene and related health conditions.

Platelet-derived growth factor receptor A (PDGFRA) mutations occur in approximately 10–15% of gastrointestinal stromal tumors (GISTs). These tumors with PDGFRA mutations have a different pathogenesis, clinical characteristics, and treatment response ...

PDGFRA/Pdgfra gene is regulated by at least seven first exons in human and mouse. our findings support a pathogenetic relationship between telocyte hyperplasia and both inflammatory fibroid polyp and PDGFRA-mutant gastrointestinal stromal tumour (GIST).

Platelet-derived growth factors (PDGF) bind to two closely related receptor tyrosine kinases, PDGF receptor α and β, which are encoded by the PDGFRA and PDGFRB genes.

Dec 2, 2023 · Our high-resolution imaging, transcriptional profiling, and organoid assays identify regional subpopulations and supportive capacities of purified mouse corpus and antral PDGFRA + cells.

Feb 25, 2025 · Pdgfra regulates multipotent cell differentiation towards chondrocytes via inhibiting Wnt9a/beta-catenin pathway during chondrocranial cartilage development. Dynamic control of adipose tissue development and adult tissue homeostasis by …

PDGFRA Fusion Genes. Chronic myeloid leukemia (CML; 608232) is characterized by the presence of the BCR (151410)/ABL (189980) fusion gene, usually in association with a t(9;22)(q34;q11) chromosomal translocation.

Feb 8, 2025 · Clinical resource with information about PDGFRA, A genome-wide association study for corneal curvature identifies the platelet-derived growth factor receptor α gene as a quantitative trait locus for eye size in white Europeans., Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore ...

Mar 13, 2025 · PDGFRA is crucial to tumorigenesis and frequently genomically altered in high-grade glioma (HGG). In a comprehensive dataset of pediatric HGG (n = 261), we detect PDGFRA mutations and/or amplifications in 15% of cases, suggesting PDGFRA as a therapeutic target.We reveal that the PDGFRA/KIT inhibitor avapritinib shows (1) selectivity for PDGFRA inhibition, …