PAX5 - Wikipedia
The PAX5 gene is a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding domain, known as the …
PAX5 Gene - GeneCards | PAX5 Protein | PAX5 Antibody
2024年12月25日 · PAX5 (Paired Box 5) is a Protein Coding gene. Diseases associated with PAX5 include Leukemia, Acute Lymphoblastic 3 and B-Lymphoblastic Leukemia/Lymphoma …
Pax5 regulates B cell immunity by promoting PI3K signaling
The transcription factor Pax5 controls B cell development, but its role in mature B cells is largely enigmatic. Here, we demonstrated that the loss of Pax5 by conditional mutagenesis in …
Pax5: the guardian of B cell identity and function - Nature
2007年4月17日 · Here we review the experimental evidence implicating Pax5 in the transcriptional control of B cell commitment, development and function as well as in B cell tumorigenesis. …
Pax5：B细胞身份和功能的守护者。,Nature Immunology - X-MOL
转录因子 Pax5 对于淋巴祖细胞向 B 淋巴细胞谱系的承诺至关重要。 Pax5 通过抑制 B 谱系“不适当”基因并同时激活 B 谱系特异性基因来发挥双重作用。
基础免疫学：B细胞发育及其调控分子 | 免疫学专题_淋巴
2020年12月7日 · pax5是一个配对盒，或结构域，转录因子，在hscs的后代中，在b细胞谱系的细胞中表达。 PAX5对B细胞的分化既有正效应，也有负作用。 参与B细胞发育的miRNA
Pax5: a master regulator of B cell development and leukemogenesis
Here, we review the different functions of Pax5 in regulating various aspects of B lymphopoiesis. At B cell commitment, Pax5 restricts the developmental potential of lymphoid progenitors to …
儿童急性淋巴细胞白血病PAX5基因的研究进展
The PAX5 gene-related B-ALL subtype PAX5 P80R was associated with a poorer prognosis in childhood cases, and patients with the PAX5alt subtype were classified as high risk more often …
EHA中国之声丨刘红星、王彤团队：破译B-ALL中PAX5基因结构异 …
2023年6月28日 · PAX5是B细胞分化过程中必需的转录因子，可以多种异常形式参与B-ALL的发生，包括序列突变（P80R）、易位形成融合基因、基因内扩增、基因丢失、外显子重复和外显 …
PAX-5介绍 - CCP-I
pax5基因b细胞分化必要成份。 它至少有4个亚型,PAX5能够编码50kDa B细胞特异活性蛋白。 PAX5正常的淋巴细胞分化过程中，从前驱至成熟B细胞中表达，但在分化终末端的浆细胞中 …