2024年12月25日 · P4HA1 (Prolyl 4-Hydroxylase Subunit Alpha 1) is a Protein Coding gene. Diseases associated with P4HA1 include Arterial Calcification, Generalized, Of Infancy, 2 and Hypoascorbemia. Among its related pathways are Collagen chain trimerization and Extracellular matrix organization.

2018年10月26日 · Collagen prolyl 4-hydroxylase (P4H) expression and collagen hydroxylation in cancer cells are necessary for breast cancer progression. Here, we show that P4H alpha 1 subunit (P4HA1) protein...

2025年2月10日 · Targeting P4HA1 enhances both adoptive and endogenous TCF1 + CD8 + T progenitor expansion while mitigating the development of exhaustion in the tumor, TDLN, and blood, enabling a notable and durable systemic anti-cancer immunity.

2024年12月26日 · Here, we identify P4HA1, encoding prolyl 4-hydroxylase 1, as a crucial regulator of CD8 + T cell differentiation strongly upregulated in tumor-draining lymph nodes (TDLNs) and hypoxic tumor microenvironment.

P4HA1 is crucial to the proper three-dimensional folding of the newly synthesized procollagen chains. P4HA1 is also involved in the remodeling of the extracellular matrix (Gilkes et al., 2013). P4HA1 is regarded as an oncogene in several cancer types.

Objective: Prolyl 4-hydroxylase, alpha polypeptide I (P4HA1), a key enzyme in collagen synthesis, comprises two identical alpha subunits and two beta subunits. However, the immunomodulatory role of P4HA1 in tumor immune microenvironment (TIME) remains unclear.

2025年2月27日 · Importantly, P4HA1 undergoes alternative splicing under hypoxia, where the inclusion of exon 9a is increased. Interestingly, involvement of ATF3 in P4HA1 splicing was also evident, as binding of ...

2025年2月27日 · The P4HA1 9a isoform leads to enhanced invasion under hypoxic conditions by increasing deposition of collagen in the ECM. These results reveal a novel hypoxia-induced HIF1ɑ-ATF3-P4HA1 axis which can potentially be exploited as a therapeutic target to impede EMT and ultimately breast cancer invasion. Hypoxia induced ATF3 regulates P4HA1 ...

Title: P4HA1 Promotes Cell Migration and Colonization in Hypopharyngeal Squamous Cell Carcinoma. Identification and verification of FN1, P4HA1 and CREBBP as potential biomarkers in human atrial fibrillation.

2021年12月13日 · Objective: Prolyl 4-hydroxylase, alpha polypeptide I (P4HA1), a key enzyme in collagen synthesis, comprises two identical alpha subunits and two beta subunits. However, the immunomodulatory role of P4HA1 in tumor immune microenvironment (TIME) remains unclear.