P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene. [5] P-selectin functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel ...

P 选择素(granular membrane protein 140,GMP140 ), 血小板活化依赖性颗粒表面膜蛋白(platelet activation dependent granule external membrane protein ,PADGEM )或CD 62 p ,是一种分子量为140K D 的膜糖蛋白, 定位于血小板的α颗粒和内皮细胞棒管状(Weibel一Palade )小体内。

Mar 21, 2024 · P-选择素又称为颗粒蛋白 GMP-140 、PAGEM、CD62P，是一种140kDa的蛋白，储存在血小板的α颗粒和内皮细胞的Weibel-Palade小体中，由活化的内皮细胞和血小板表达。凝血酶、组胺或补体等介质可诱导P-选择素迅速重新分布到质膜。

选择素（英語： selectins ，又译为选择蛋白，或称为表面抗原分化簇-62，即CD62）是一个细胞粘附分子CAM家族，包括有E-選擇素、L 選擇素、P選擇素等。 所有的选择素都是单链跨膜 糖蛋白 ，与 C-型凝集素 属性类似，有着相似的 N-末端 和钙依赖性 [ 2 ] 。

P-Selectin is a 140-kDa integral membrane glycoprotein that plays a role in selectin-dependent leukocyte adhesion. AI generated definition based on: Comprehensive Medicinal Chemistry III, 2017

Jul 17, 2024 · P-selectin interacts with a high affinity ligand, P-selectin glycoprotein ligand 1 (PSGL-1), expressed on the surfaces of all leukocytes, facilitating the initial “capture and rolling” step in the leukocyte–endothelial cell adhesion cascade. 2 Although P-selectin is an essential mediator of innate immune responses, sustained expression of ...

p-选择素，又名cd62p、颗粒膜蛋白140 (gmp-140)和血小板活化依赖的颗粒外膜蛋白(padgem)，是一种细胞表面糖蛋白，在淋巴细胞迁移到组织过程中发挥关键作用。

May 31, 2022 · Nature Communications - P-selectin recruits leucocytes to regions of blood vessel damage. Using single molecule imaging, we find newly secreted P-selectin spreads rapidly across the plasma...

P-selectin belongs to the family of selectin adhesion molecules, and is expressed by platelets and endothelial cells on stimulation. This pattern of expression may indicate an involvement of this molecule in inflammation and coagulation. Data from mice lacking P-selectin expression confirmed this as …

May 1, 2022 · P-Selectin/P-Selectin ligand axis promotes cancer metastasis via platelet-cancer cell interactions. P-Selectin mediates cancer immunity. Targeting P-Selectin improves the efficacy and specificity of anti-cancer and anti-thrombosis nanomedicines.