P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene. [5] P-selectin functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial …

P-selectin, the largest selectin, is stored in α-granules of platelets and in Weibel–Palade bodies of endothelial cells, and is translocated to the cell surface of activated endothelial cells and …

P-Selectin is a 140-kDa integral membrane glycoprotein that plays a role in selectin-dependent leukocyte adhesion. AI generated definition based on: Comprehensive Medicinal Chemistry III, …

P-selectin is stored in membranes of α granules of platelets and Weibel-Palade bodies of endothelial cells. When mediators such as thrombin or histamine activate these cells, the …

2024年7月17日 · P-selectin interacts with a high affinity ligand, P-selectin glycoprotein ligand 1 (PSGL-1), expressed on the surfaces of all leukocytes, facilitating the initial “capture and …

This mini-review highlights the major structural differences between E- and P-selectin and summarizes the resulting strategies for the design of selectin antagonists.

P-selectin belongs to the family of selectin adhesion molecules, and is expressed by platelets and endothelial cells on stimulation. This pattern of expression may indicate an involvement of this …

2022年5月31日 · Nature Communications - P-selectin recruits leucocytes to regions of blood vessel damage. Using single molecule imaging, we find newly secreted P-selectin spreads …

P-selectin, an inflammatory cell adhesion molecule responsible for leukocyte recruitment and platelet binding (11–14), is expressed constitutively in ECs, where it is stored in intracellular …

P-selectin (CD62P) is a member of the selectin family of cell adhesion molecules. It is expressed on stimulated endothelial cells and activated platelets and mediates leukocyte rolling on …