P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene. [5] P-selectin functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel ...

P-selectin, the largest selectin, is stored in α-granules of platelets and in Weibel–Palade bodies of endothelial cells, and is translocated to the cell surface of activated endothelial cells and platelets. E-selectin is not expressed under baseline conditions, except in skin microvessels, but is rapidly induced by inflammatory cytokines.

P-Selectin is a 140-kDa integral membrane glycoprotein that plays a role in selectin-dependent leukocyte adhesion. AI generated definition based on: Comprehensive Medicinal Chemistry III, 2017

P-selectin is stored in membranes of α granules of platelets and Weibel-Palade bodies of endothelial cells. When mediators such as thrombin or histamine activate these cells, the granules fuse with the plasma membrane and P-selectin is rapidly redistributed to the cell surface.

2024年7月17日 · P-selectin interacts with a high affinity ligand, P-selectin glycoprotein ligand 1 (PSGL-1), expressed on the surfaces of all leukocytes, facilitating the initial “capture and rolling” step in the leukocyte–endothelial cell adhesion cascade. 2 Although P-selectin is an essential mediator of innate immune responses, sustained expression of ...

This mini-review highlights the major structural differences between E- and P-selectin and summarizes the resulting strategies for the design of selectin antagonists.

P-selectin belongs to the family of selectin adhesion molecules, and is expressed by platelets and endothelial cells on stimulation. This pattern of expression may indicate an involvement of this molecule in inflammation and coagulation. Data from mice lacking P-selectin expression confirmed this as …

2022年5月31日 · Nature Communications - P-selectin recruits leucocytes to regions of blood vessel damage. Using single molecule imaging, we find newly secreted P-selectin spreads rapidly across the plasma...

P-selectin, an inflammatory cell adhesion molecule responsible for leukocyte recruitment and platelet binding (11–14), is expressed constitutively in ECs, where it is stored in intracellular granules known as Weibel-Palade bodies.

P-selectin (CD62P) is a member of the selectin family of cell adhesion molecules. It is expressed on stimulated endothelial cells and activated platelets and mediates leukocyte rolling on stimulated endothelial cells and heterotypic aggregation of activated platelets onto leukocytes.