The oxytocin receptor, also known as OXTR, is a protein which functions as receptor for the hormone and neurotransmitter oxytocin. [4][5] In humans, the oxytocin receptor is encoded by the OXTR gene [6][7] which has been localized to human chromosome 3p25. [8]

6 天之前 · Oxytocin binds to the oxytocin receptor (OXTR), a G protein-coupled receptor (GPCR) primarily linked to the Gq/11 signaling pathway. This receptor is widely distributed in the brain, with high expression in regions such as the amygdala, hypothalamus, nucleus accumbens, and prefrontal cortex—areas integral to social cognition, emotional ...

The Oxytocin Receptor System: Structure, Function, and Regulation. Physiol Rev 81: 629–683, 2001.—The neurohypophysial peptide oxytocin (OT) and OT-like hormones facilitate reproduction in all vertebrates at several levels.

At the molecular level, oxytocin activates specific receptors, influencing neuronal activity and neurotransmitter release, impacting social behavior like trust and empathy.

The oxytocin receptor (OXTR) is a G protein-coupled receptor with a diverse repertoire of intracellular signaling pathways, which are activated in response to binding oxytocin (OXT) and a similar nonapeptide, vasopressin.

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

The OXTR, a 7-transmembrane G protein-coupled receptor capable of binding to either G i or G q proteins, activates a set of signaling cascades, such as the MAPK, PKC, PLC, or CaMK pathways, which converge on transcription factors like CREB or MEF-2.

2018年5月29日 · The oxytocin receptor is a 389-amino acid G-protein coupled transmembrane receptor, enabling the activation of a number of different intracellular secondary messengers facilitating the oxytocin pathway .

2025年1月6日 · Oxytocin function is associated with a range of human traits and is often indexed by common polymorphisms of the receptor gene OXTR. Little is known however about the functional significance of these polymorphisms.

Crystal structure of the human oxytocin receptor. The peptide hormone oxytocin modulates socioemotional behavior and sexual reproduction via the centrally expressed oxytocin receptor (OTR) across several species.