Oncostatin-M specific receptor subunit beta also known as the Oncostatin M receptor (OSMR), is one of the receptor proteins for oncostatin M, that in humans is encoded by the OSMR gene. [5] [6] OSMR is a member of the type I cytokine receptor family.

Dec 25, 2024 · OSMR (Oncostatin M Receptor) is a Protein Coding gene. Diseases associated with OSMR include Amyloidosis, Primary Localized Cutaneous, 1 and Primary Cutaneous Amyloidosis . Among its related pathways are Akt Signaling and Interleukin-6 family signaling .

Apr 21, 2021 · osmr，抑瘤素m受体β亚基，是 i型细胞因子受体 家族中的一员。 OSMR包含四个III型纤连蛋白结构域，在所有神经细胞、成纤维细胞、 上皮细胞 和多种Tumour细胞系中表达较高。

Sep 12, 2024 · From these mice, we isolated HSCs by flow cytometry, stimulated with recombinant OSM or vehicle for 1 hour, and assessed gene expression changes in control versus Osmr knockout HSCs by RNA-seq.

Jun 5, 2024 · Taken together, our results demonstrate that OSMR is an important mediator of cell survival and chemoresistance mechanism in ovarian cancer cells and inhibiting the oncogenic actions of OSMR...

Aug 17, 2020 · Nature Communications - The suppression of the receptor for oncostatin M (OSMR) can prevent glioblastoma cell growth. Here, the authors demonstrate a role for OSMR in modulating glioma stem...

The OSMR gene provides instructions for making a protein called oncostatin M receptor beta subunit (OSMRβ). This protein is one piece (subunit) of both the oncostatin M (OSM) receptor type II and the interleukin-31 (IL-31) receptor.

制瘤素 M 受体： 该基因编码 I 型细胞因子受体家族的成员。编码的蛋白质与白介素 6 信号转导异二聚化形成 II 型制瘤素 M 受体，并与白介素 31 受体 A 异二聚化形成白介素 31 受体，从而转导制瘤素 M 和白介素 31 诱导的信号事件。该基因的突变与家族性原发性局部皮肤淀粉样变性有关。已 …

这个基因编码i型细胞因子受体家族的一员。编码的蛋白质与白细胞介素6信号转导子异二聚化，形成ii型奥卡坦m受体，并与白细胞介素31受体a形成白细胞介素31受体，从而传递奥卡坦m和白细介素31诱导的信号事件。这个基因的突变与家族性原发性局部皮肤淀粉样病变有关。

OSMR的作用机制主要是通过与Oncostatin M (OSM) 结合，激活其下游信号传导。 OSMR与OSM的结合可以激活JAK/STAT、MAPK和PI3K等信号通路，进而调控细胞的增殖、分化和存活。