Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are an actionable biomarker for cancer therapy and can be found in over 25 different types of cancer, regardless of where they are located in the body. 1,2. What is NTRK? What are NTRK fusion-positive tumors, and what is their prevalence? How are NTRK fusion-positive tumors identified?

The identification of cancer patients harboring NTRK gene fusions is constantly growing, especially with the advent of NTRK inhibitors. This has promisingly provided a rationale for personalized therapeutics that improved outcomes in settings with this signature.

In this Review, we discuss the biology of NTRK fusions, strategies to target these drivers in the treatment-naive and acquired-resistance disease settings, and the unique safety profile of TRK inhibitors.

NTRK fusions are clinically actionable: first-generation TRK tyrosine kinase inhibitors (larotrectinib or entrectinib) result in histology-agnostic responses in both adult and paediatric patients with NTRK fusion-positive cancers.

Sep 16, 2021 · Neurotrophic tropomyosin-receptor kinase (NTRK) genes encode a family of transmembrane-receptor tyrosine kinases that play an important role in neural development. The first...

Neurotrophic tyrosine receptor kinase (NTRK) has been a remarkable therapeutic target for treating different malignancies, playing an essential role in oncogenic signaling pathways.

Jul 20, 2021 · Neurotrophic tropomyosin receptor kinase (NTRK) gene fusions are rare oncogenic drivers in solid tumours. This study aimed to interrogate a large real-world database of comprehensive genomic...

NTRK gene fusions are one such targetable aberration. The neurotrophin receptor tyrosine kinase (NTRK) family is made up of 3 genes crucial to nervous system development and physiology. These genes - NTRK1, NTRK2, and NTRK3 - encode …

Mar 13, 2023 · NTRK gene fusions are rare somatic mutations found across cancer types with promising targeted therapies emerging. Healthcare systems face significant challenges in integrating these treatments,...

NTRK is an important biomarker that can impact lung what treatment options. The videos above were produced in 2020. For the latest treatment options, speak with your doctor. What is an NTRK gene fusion? Errors in the NTRK gene are one type of lung cancer biomarker.