Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are an actionable biomarker for cancer therapy and can be found in over 25 different types of cancer, regardless of where they are located in the body. 1,2. What is NTRK? What are NTRK fusion-positive tumors, and what is their prevalence? How are NTRK fusion-positive tumors identified?

The identification of cancer patients harboring NTRK gene fusions is constantly growing, especially with the advent of NTRK inhibitors. This has promisingly provided a rationale for personalized therapeutics that improved outcomes in settings with this signature.

2021年9月16日 · Neurotrophic tropomyosin-receptor kinase (NTRK) genes encode a family of transmembrane-receptor tyrosine kinases that play an important role in neural development. The first...

NTRK fusions are clinically actionable: first-generation TRK tyrosine kinase inhibitors (larotrectinib or entrectinib) result in histology-agnostic responses in both adult and paediatric patients with NTRK fusion-positive cancers.

The NTRKers is a global, non-profit patient group, founded by patients and loved ones living with NTRK gene fusion cancer, and supported by leading clinical experts. Changes to the NTRK gene can cause normal cells to transform into cancer cells no matter where they are in the body.

In this review, we discuss the normal function and physiology of TRK receptors, the biology behind NTRK gene fusions, the mechanisms by which NTRK gene fusions become oncogenic drivers in cancer, and the incidence and prevalence of NTRK gene fusions in a variety of cancers.

NTRK gene fusions are one such targetable aberration. The neurotrophin receptor tyrosine kinase (NTRK) family is made up of 3 genes crucial to nervous system development and physiology. These genes - NTRK1, NTRK2, and NTRK3 - encode …

2021年7月20日 · Neurotrophic tropomyosin receptor kinase (NTRK) gene fusions are rare oncogenic drivers in solid tumours. This study aimed to interrogate a large real-world database of comprehensive genomic...

2023年3月13日 · NTRK gene fusions are rare somatic mutations found across cancer types with promising targeted therapies emerging. Healthcare systems face significant challenges in integrating these treatments,...

NTRK is an important biomarker that can impact lung what treatment options. The videos above were produced in 2020. For the latest treatment options, speak with your doctor. What is an NTRK gene fusion? Errors in the NTRK gene are one type of lung cancer biomarker.