Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene. [5][6][7] The neuregulins, including NRG4, activate erb-b2 receptor tyrosine kinase 4 (ERBB4) to initiating cell signaling through cytosolic tyrosine phosphorylation. [7]

Nov 17, 2014 · Here we show that neuregulin 4 (Nrg4), a member of the epidermal growth factor (EGF) family of extracellular ligands, is highly expressed in adipose tissues, enriched in brown fat and markedly...

Dec 25, 2024 · NRG4 (Neuregulin 4) is a Protein Coding gene. Diseases associated with NRG4 include Diabetes Mellitus and Lysosomal Storage Disease. Among its related pathways are Signaling by ERBB2 KD Mutants and Constitutive Signaling by Aberrant PI3K in Cancer.

摘 要：神经调节蛋白4 (neuregulin 4, NRG4)是一种含有表皮生长因子(epidermal growth factor, EGF)类似区域的蛋白分子，主要 在棕色脂肪细胞中表达和分泌。 NRG4通过与EGF的受体ErbB4 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4)

NRG4是神经调节蛋白 NRG 家族成员之一，主要表达在特定的外周组织，其中以 棕色脂肪组织 表达水平最高。 NRG4 基因敲除小鼠 体重增长更快，肝内甘油三酯沉积加重，胰岛素抵抗增加，糖耐量下降，然而，NRG4在人群中的保护作用尚未得到验证，其如何参与人类代谢性疾病的发生尚不清楚。 该研究在大样本人群中通过基因芯片检测分析，发现 NRG4 基因所在的染色体15 q24.2区域为代谢紊乱热点区域，与血甘油三酯、r-GT及HOMA-IR等代谢指标密切相关，提示 …

Mar 1, 2024 · Neuregulin 4 (Nrg4), an epidermal growth factor (EGF) family member, can bind to and activate the ErbB4 receptor tyrosine kinase. Nrg4 has five different isoforms by alternative splicing and performs a wide variety of functions.

Sep 7, 2022 · ” 研究小组确定了一种作为疾病进展检查点的激素，它似乎具有治疗的潜力：neuregulin 4，或NRG4。 研究小组先前发现，NRG4可以保护小鼠肝脏免受NASH的影响，而这种激素的减少或丢失会导致更严重的肝脏疾病。

Nov 13, 2022 · Abstract: Neuregulin 4 (NRG4) is a novel fat secretion factor that is mainly expressed and secreted in brown fat. NRG4 specifically binds to epidermal growth factor receptor 4 (ErbB4) on hepatocyte membranes and activates downstream signaling pathways to relieve hepatic steatosis by inhibiting de novo synthesis of lipids, increasing fatty acid ...

Neuregulin 4 (Nrg4), a novel adipokine secreted mainly by brown adipose tissue (BAT), has recently been characterized as having an important effect on the regulation of energy homeostasis and glucolipid metabolism.

Neuregulin 4 (Nrg4), a novel brown fat-enriched hormone, plays a key role in the modulation of glucose and lipid metabolism and energy balance. Recent data have demonstrated that the expression of Nrg4 is substantially down-regulated in mouse and human obesity, making its regulatory aspect intriguin …