Dec 25, 2024 · NOTCH1 (Notch Receptor 1) is a Protein Coding gene. Diseases associated with NOTCH1 include Aortic Valve Disease 1 and Adams-Oliver Syndrome 5. Among its related …

The NOTCH1 gene provides instructions for making a protein called Notch1, a member of the Notch family of receptors. Receptor proteins have specific sites into which certain other …

Mar 24, 2022 · NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription of target genes. NOTCH signaling deeply participates in the …

NOTCH1 is a cell surface receptor that releases its intracellular domain as transcription factor upon activation. With the advent of next-generation sequencing, the NOTCH1 gene was found …

Mar 10, 2025 · Similarly, Notch1 signalling is involved in neuroectoderm segregation by refining germ layer boundaries during Xenopus laevis gastrulation. Here, a domain of ligand …

In CLL, NOTCH1 mutations represent a validated prognostic marker and a potential predictive marker for anti-CD20-based therapies, as pathological alterations of the Notch pathway can …

Notch1, a member of the Notch family, is implicated in many types of cancer, including breast cancer (especially triple-negative breast cancer), leukemias, brain tumors, and many others. …

Mar 3, 2025 · With a novel HCC mouse model and validation in patients with HCC, we demonstrate that NOTCH1 disrupts antitumor immunity specifically in females through a …

Mar 8, 2025 · Title: Notch1 signaling pathway promotes growth and metastasis of gastric cancer via modulating CDH5. Prognostic Impact of Notch1 Intracellular Domain, P63, and c-MYC in …

Notch1 expression correlated closely with colorectal cancer differentiation; Notch1 controls early T cell development, in part by regulating the stage- and lineage-specific expression of IL-7Ralpha.