Metastasis suppressor genes (MSGs) inhibit different biological processes during metastatic progression without globally influencing development of the primary tumor. The first MSG, NM23 (non-metastatic clone 23, isoform H1) or now called NME1 ...

2021年3月22日 · Non-metastatic protein 23 H1 (Nm23-H1), a housekeeping enzyme, is a nucleoside diphosphate kinase-A (NDPK-A). It was the first identified metastasis suppressor protein.

NM23 is the first discovered metastasis suppressor gene, which does not affect the growth of primary tumor but a powerful inhibitor of metastases of tumors. Altered NM23 expression was found to be closely related to various tumor metastases, including NSCLC.

In this light, further understanding of Lamins/TRF1/2/NM23-H2 or FEN1/NM23-H2 associations might provide meaningful insights into the role of NM23 proteins in telomere biology. Finally, multiple pieces of evidence of the mitochondrial NM23 protein suggests an …

2021年3月1日 · This review summarized and discussed the regulatory mechanisms of NM23-H1 in cancer including transcriptional activation, subcellular location, enzymatic activity, and protein degradation, which significantly modulate its anti-metastatic function.

Group I NM23 genes encode enzymes with evolutionarily highly conserved nucleoside diphosphate kinase (NDPK) activity. In this review we summarize how results from NDPKs in model organisms converged on human NM23 studies.

2020年3月18日 · The metastasis suppressor gene NME/nm23/NDPK was discovered in 1988 by Steeg et al, 1 from the analysis of murine melanoma K-1735 cells based on its differential expression with respect to metastatic potential. The first identified member of the nm23 metastasis suppressor gene

2010年6月6日 · Nm23-H1 enhances the transcriptional activity of a multimerized p53 responsive cis-acting DNA element in human cell lines. Approximately 60% of the genes from the p53 related pathway gene array were upregulated. Can Nm23-H1 modulate the transcriptional activity at p53 responsive genes?

The first metastasis suppressor gene confirmed was nm23, also known as NDP kinase. Using in vitro assays, nm23 overexpression resulted in reduced anchorage-independent colonization in response to TGF-beta, reduced invasion and motility in response to multiple factors, and increased differentiation.

Nm23-H1 is a metastasis-suppressant gene whose inactivation can affect microtubule polymerization, leading to chromosomal aberrations and aneuploidy formation, thereby promoting tumor metastasis. Nm23-H1 can inhibit tumor metastasis and tumor progression in a variety of human tumors, but its role in NSCLC remains controversial.