Dec 25, 2024 · NFKBIA (NFKB Inhibitor Alpha) is a Protein Coding gene. Diseases associated with NFKBIA include Ectodermal Dysplasia And Immunodeficiency 2 and Hypohidrotic Ectodermal Dysplasia With Immunodeficiency. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and TNFR1 Pathway.

Sep 21, 2020 · Emerging studies indicate that dysregulated NF-κB activity causes inflammation-related diseases as well as cancers, and NF-κB has been long proposed as the potential target for therapy of...

Aug 1, 2013 · The NFKBIA gene provides instructions for making one piece (the alpha subunit) of the IKK protein complex, which is a group of related proteins that regulates the activity of nuclear factor-kappa-B. Learn about this gene and related health conditions.

Our findings represent the first characterization of NFKBIA and IκBα as maternal effectors in both the bovine oocyte and embryo. We suggest a role for NFKBIA as a marker of NF-κB/p65 activation in the human oocyte and early embryo.

Feb 20, 2025 · HIV-1 Tat upregulates the expression of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA, IkappaB alpha) in human primary T cells PubMed tat

Dec 10, 2024 · Phosphorylated IκBα predicts poor prognosis in activated B-cell lymphoma and its inhibition with thymoquinone induces apoptosis via ROS release. Hussain AR, Uddin S, Ahmed M, Al-Dayel F, Bavi PP, Al-Kuraya KSHussain AR, et al. PLoS One, 2013. PMID 23555990. Silenced expression of NFKBIA in lung adenocarcinoma patients with a never-smoking history.

Gene ID: 4792, updated on 9-Feb-2025. This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses.

The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm.

Jan 18, 2021 · DNA damage induces two kinetically and functionally distinct phases of NF‐κB activation. The first is anti‐apoptotic and driven by the IKK cascade, while the second inflammatory response in senescence is IKK and proteasome independent, triggered by repression of IκBα mRNA synthesis.

该基因编码 NF-kappa-B 抑制剂家族的成员，该家族包含多个锚蛋白重复结构域。 编码的蛋白质与 REL 二聚体相互作用，抑制参与炎症反应的 NF-kappa-B/REL 复合物。 编码的蛋白质通过核定位信号和 CRM1 介导的核输出在细胞质和细胞核之间移动。 已在伴有 T 细胞免疫缺陷的常染色体显性遗传病的外胚层发育不良无汗症中发现该基因的突变。 [RefSeq 提供，2011 年 8 月] This …