Neuron-Specific Enolase as a Biomarker: Biochemical and Clinical ...
Neuron-specific enolase (NSE) is known to be a cell specific isoenzyme of the glycolytic enzyme enolase. In vertebrate organisms three isozymes of enolase, expressed by different genes, are present: enolase α is ubiquitous; enolase β is muscle-specific and enolase γ is neuron-specific.
Neuron-Specific Enolase - an overview | ScienceDirect Topics
Neuron-specific enolase (NSE) is the γ-subunit of the enolase enzyme involved in the glycolytic pathway and is characteristic of neural cells. Several tumors have been shown to be immunoreactive with NSE including medullary thyroid (C-cell) tumors, chordomas, and ganglioneuroblastomas.
Neuron-Specific Enolase—What Are We Measuring? - PMC
Since the discovery of the neuron-specific protein by Moore and McGregor in 1965, tens of thousands of studies have investigated the basic and applied significance of neuron-specific enolase (NSE). This promising biomarker, according to many ...
Enolase 2 - Wikipedia
Neuron-specific enolase (NSE) immunostaining of a cerebellar hemangioblastoma. Detection of NSE with antibodies can be used to identify neuronal cells and cells with neuroendocrine differentiation. NSE is produced by small-cell carcinomas, which are neuroendocrine in origin.
NSE - Overview: Neuron-Specific Enolase, Serum - Mayo Clinic …
Neuron-specific enolase (NSE) is a 78 kDa gamma-homodimer and represents the dominant enolase-isoenzyme found in neuronal and neuroendocrine tissues. Its levels in other tissues, except erythrocytes, are negligible.
Neuron Specific Enolase - an overview | ScienceDirect Topics
Neuron-Specific Enolase (NSE) is the neuron-specific isomer of the glycolytic enzyme 2-phospho-d-glycerate hydrolyase or enolase, which is expressed in neurons and neuroendocrine cells. Serum NSE levels are frequently elevated in patients with small-cell lung cancer (SCLC) and in 30–50% of patients with neuroendocrine tumours, particularly ...
Neuron-Specific Enolase as an Immunohistochemical Marker Is …
Neuron-specific enolase (NSE) being a cytosolic marker may be useful in this setting. NSE is by many considered nonspecific, due to the finding of this marker in tumors considered not to be of neuroendocrine origin.
Multifunctional neuron-specific enolase: its role in lung diseases
Neuron-specific enolase (NSE), also known as gamma (γ) enolase or enolase-2 (Eno2), is a form of glycolytic enolase isozyme and is considered a multifunctional protein. NSE is mainly expressed in the cytoplasm of neurons and neuroendocrine cells, ...
Neuron-Specific Enolase, Serum - Mayo Clinic Laboratories
Neuron-specific enolase (NSE) is a 78 kDa gamma-homodimer and represents the dominant enolase-isoenzyme found in neuronal and neuroendocrine tissues. Its levels in other tissues, except erythrocytes, are negligible. The biological half-life of NSE in …
New Insights into the Role of Neuron-Specific Enolase in Neuro …
Neuron specific enolase (NSE) is a marker for neurons and peripheral neuroendocrine cells that exist as either γγ or αγ dimeric isozymes. While the γγ form of NSE is expressed in neurons, the αγ form is expressed in microglia, oligodendrocytes, and astrocytes [3, 4, 5].
- 某些结果已被删除