Dec 25, 2024 · NEU1 (Neuraminidase 1) is a Protein Coding gene. Diseases associated with NEU1 include Neuraminidase Deficiency and Glycoproteinosis. Among its related pathways are Diseases of glycosylation and Synthesis of substrates in N-glycan biosythesis.

The NEU1 gene provides instructions for making an enzyme called neuraminidase 1 (NEU1), which is found in lysosomes. Learn about this gene and related health conditions.

Mar 27, 2023 · Here, we characterize the role of neuraminidase 1 (NEU1) in unilateral ureteral obstruction (UUO) and folic acid (FA)-induced renal fibrosis mouse models. We find that NEU1 is significantly...

May 19, 2023 · Neuraminidase-1 (sialidase-1 or NEU1) is a ubiquitously expressed mammalian sialidase located in lysosomes and on the cell membrane. Because of its modulation of multiple signaling processes, it is a potential therapeutic target for cancers and immune disorders.

Neuraminidase 1 (NEU1) is a lysosomal sialidase that cleaves terminal α-linked sialic acid residues from sialylglycans. NEU1 is biosynthesized in the rough endoplasmic reticulum (RER) lumen as an N-glycosylated protein to associate with its protective protein/cathepsin A (CTSA) and then form a lysos …

Neu1 regulates cell growth and death, and facilitates cancer progression by modulating the expression levels of cadherins. 31 rare variants in eight genes (mainly in MYBPC3, TNNT2 and LMNA) were identified, in 28 patients (26%).

Structurally distinct as a large family of mammalian proteins, neuraminidases (NEU1 through NEU4) possess dissimilar yet overlapping profiles of tissue expression, cellular/subcellular localization, and substrate specificity.

Dec 26, 2023 · Neuraminidase 1 (NEU1) is a lysosomal sialidase that cleaves terminal α-linked sialic acid residues from sialylglycans.

Jul 26, 2024 · Structurally distinct as a large family of mammalian proteins, neuraminidases (NEU1 through NEU4) possess dissimilar yet overlapping profiles of tissue expression, cellular/subcellular localization, and substrate specificity.

The NEU1 gene provides instructions for making an enzyme called neuraminidase 1 ( NEU1), which is found in lysosomes. Lysosomes are compartments within cells that use enzymes to digest and recycle materials.