The NDUFS3 gene encodes a protein subunit consisting of 263 amino acids. This protein is synthesized in the cytoplasm and then transported to the mitochondria via a signal peptide. Two mutations that occur in its highly conserved C-terminal region, T145I and R199W, are causally linked to Leigh syndrome and optic atrophy. Nonetheless, despite ...

Dec 25, 2024 · NDUFS3 (NADH:Ubiquinone Oxidoreductase Core Subunit S3) is a Protein Coding gene. Diseases associated with NDUFS3 include Mitochondrial Complex I Deficiency, Nuclear Type 8 and Isolated Complex I Deficiency. Among its related pathways are Signaling by Rho GTPases and Complex I biogenesis.

该基因编码线粒体 NADH 的一种铁硫蛋白 (IP) 成分：泛醌氧化还原酶 (复合物 I) 。 该基因的突变与由线粒体复合物 I 缺陷引起的 Leigh 综合征有关。 [RefSeq 提供，2009 年 4 月] This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I).

a novel, biomarker potential of a mitochondrial complex I subunit protein, NDUFS3 - as a robust indicator of breast cancer progression and invasiveness as well as of hypoxia/necrosis in clinical specimens of invasive ductal carcinoma, was uncovered.

Mar 5, 2024 · Clinical resource with information about NDUFS3, Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index., Mitochondrial complex 1 deficiency, nuclear type 8, and available tests.

To understand the mechanisms regulating the extremely intricate biogenesis of this fundamental bioenergetic machine, we analyze the structural and functional consequences of the ablation of NDUFS3, a non-catalytic core subunit.

Apr 20, 2021 · To understand the mechanisms regulating the extremely intricate biogenesis of this fundamental bioenergetic machine, we analyze the structural and functional consequences of the ablation of NDUFS3, a non-catalytic core subunit.

烟酰胺腺嘌呤二核苷酸脱氧酶铁-硫蛋白3 ( NDUFS3)是线粒体烟酰胺腺嘌呤二核苷酸脱氢酶Ⅰ复合物的基本亚单位之一,在线粒体Ⅰ型呼吸过程中至关重要.早期研究中该基因突变主要导致Leigh综合征等神经变性疾病.近年来观察到NDUFS3在肿瘤细胞中表达下调,推测可能与肿瘤发生发展存在密切关系。 引用本文: 王培, 程晓东, 谢幸. 线粒体蛋白NDUFS3与肿瘤 [J] . 国际肿瘤学杂志,2012,39 ( 09 ): 647-650. DOI: 10.3760/cma.j.issn.1673-422x.2012.09.002.

Mar 13, 2019 · NADH脱氢酶 [泛醌]铁硫蛋白3 (NADH dehydrogenase [ubiquinone] ferrithionein 3,NDUFS3)是线粒体复合体Ⅰ的核心亚基,直接参与呼吸链的电子传递的过程,在人类各组织器官中的表达水平高低不一.NDUFS3参与肿瘤的发生发展,与细胞活性氧ROS (reactive oxygen species)水平,三磷酸腺苷 (adenosine triphosphate,ATP)生成以及Warburg效应密切相关.本文综述了NDUFS3在肿瘤中的作用及其可能分子机制的研究进展.

Mar 15, 2013 · Here we report a genetically-defined model system based on the gene-silencing of a mitochondrial complex I subunit, NDUFS3, where we demonstrate the onset of metabolic switch in isogenic human embryonic kidney cells by differential expression of NDUFS3.