KO studies have confirmed a role for both Nav1.7 and Nav1.8 in the pathophysiology of inflammatory pain with these animals displaying reduced/attenuated inflammatory pain behaviours. A better understanding regarding the contributions of these channels in pathological pain is beginning to develop.

Dec 1, 2024 · In this review, we summarize the latest developments in Na v 1.8-selective inhibitors, focusing on the druggable sites and mechanisms that confer subtype specificity.

Aug 2, 2023 · We describe the preclinical characterization of VX-548, an oral, highly selective inhibitor of Na V 1.8, and we report the results of two phase 2 trials evaluating the efficacy and safety of...

Jan 21, 2025 · Voltage-gated sodium (Nav) channels in the peripheral nervous system-Nav1.7, Nav1.8, and Nav1.9-play crucial roles in pain signaling. Among these, Nav1.8 has shown promise due to its rapid recovery from inactivation and role in repetitive firing, with recent clinical studies providing proof-of-principal that block of Nav1.8 can reduce pain in ...

Nav1.8 is a voltage-gated sodium channel (VGSC) that is important for neuronal excitability in nociception. Alterations in Nav1.8 sodium current in sensory neurons affect normal pain-signaling and underlie the pathophysiology of pain states, such …

Mar 29, 2021 · Evidence from human genetic pain disorders shows that voltage-gated sodium channel α-subtypes Nav1.7, Nav1.8 and Nav1.9 are important in the peripheral signalling of pain.

Seven Na v 1.8 mutations were identified in 9 subjects within a series of 104 patients with painful predominantly small-fiber neuropathy. Three mutations met criteria for potential pathogenicity based on predictive algorithms and were assessed by voltage and current clamp.

The NaV1.8 sodium channel, encoded by gene SCN10A, was initially termed sensory neuron–specific (SNS) due to prominent expression in primary sensory neurons including dorsal root ganglion (DRG) neurons.

The role of Na v 1.7 and Na v 1.8 in the generation and maintenance of abnormal neuronal electrogenesis and hyperexcitability highlights the importance of these channels in the development of pathological pain.

Feb 2, 2016 · The NaV1.8 sodium channel, encoded by gene SCN10A, was initially termed sensory neuron-specific (SNS) due to prominent expression in primary sensory neurons including dorsal root ganglion (DRG) neurons. Early studies on rodent NaV1.8 demonstrated depolarized voltage dependence of channel inactivatio …