Nuclear pore complex protein Nup98-Nup96 is a protein that in humans is encoded by the NUP98 gene. [5] Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is composed of approximately 30 unique proteins collectively known as …

2024年12月25日 · NUP98 (Nucleoporin 98 And 96 Precursor) is a Protein Coding gene. Diseases associated with NUP98 include Hematologic Cancer and Childhood Acute Myeloid Leukemia. Among its related pathways are Transport of the SLBP independent Mature mRNA and EML4 and NUDC in mitotic spindle formation.

2011年12月8日 · NUP98 is known to be fused to at least 28 different partner genes in patients with hematopoietic malignancies, including acute myeloid leukemia, chronic myeloid leukemia in blast crisis, myelodysplastic syndrome, acute lymphoblastic leukemia, …

2024年5月14日 · Nucleoporin 98 (NUP98, chromosome 11p15) fusion oncoproteins also called NUP98 rearrangements (NUP98r) have already been identified in a spectrum of hematologic malignancies for a long time,...

NUP98 translocations are common genetic alterations in pediatric AML that are associated with dismal prognosis. NUP98 fusions often co‐occur with a set of additional somatic mutations that confer a proliferative advantage to AML cells and add more complexity to the disease, demanding more effective therapeutics. Though novel insights into the ...

Nup98, which exhibits transcription-dependent mobility at the NPC but can also bind chromatin away from the nuclear envelope, is frequently involved in chromosomal translocations in a subset of patients suffering from acute myeloid leukemia (AML).

2020年11月12日 · Nucleoporin 98 (NUP98) fusion oncoproteins are observed in a spectrum of hematologic malignancies, particularly pediatric leukemias with poor patient outcomes.

2023年8月1日 · NUP98 fusions comprise a family of rare recurrent alterations in AML, associated with adverse outcomes. In order to define the underlying biology and clinical implications of this family of fusions, we performed comprehensive transcriptome, epigenome, and immunophenotypic profiling of 2,235 children …

NUP98-NSD1 is a recurrent genetic abnormality with significant clinical prognostic significance; REVIEW: Nup98 controls gene expression by regulating a DExH/D-box protein; A novel biomarker, NUP98, can predict response to anthracycline based chemotherapy in …

2024年9月27日 · NUP98, a nuclear pore complex component, functions as abnormal transcription factor in fusion proteins, and its partner genes in NUP98 fusions also possess transcription-related domains. 1 Acute myeloid leukemia (AML) with NUP98 rearrangement (NUP98r) is a newly introduced diagnostic entity in both the fifth edition of the World Health ...