
NR3C1 Gene - GeneCards | GCR Protein | GCR Antibody
2024年12月25日 · NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1) is a Protein Coding gene. Diseases associated with NR3C1 include Glucocorticoid Resistance, Generalized and Primary Hyperaldosteronism. Among its related pathways are Gene expression (Transcription) and Infectious disease.
Glucocorticoid receptor - Wikipedia
The glucocorticoid receptor (GR or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response.
NR3C1 nuclear receptor subfamily 3 group C member 1 [Homo …
2025年2月9日 · It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants …
NR3C1 nuclear receptor subfamily 3 group C member 1 [ (human)]
Gene ID: 2908, updated on 9-Feb-2025. This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors.
Glucocorticoid receptor gene ( NR3C1 ) methylation processes …
2015年8月1日 · The NR3C1 gene codes for the glucocorticoid receptor, a key element involved in several steps of HPA axis modulation. In this review, we gather existing evidence linking NR3C1 methylation pattern with either ELS or psychopathology.
Glucocorticoid receptor gene (NR3C1) DNA methylation in
The glucocorticoid receptor gene (NR3C1) is a critical component of the stress response system. Cytosine methylation of NR3C1 has been repeatedly associated with trauma and mental disorders, including major depression, post-traumatic stress disorder, anxiety, and personality disorders, suggesting th …
NUCLEAR RECEPTOR SUBFAMILY 3, GROUP C, MEMBER 1; NR3C1 …
Bray and Cotton (2003) reported that a total of 15 missense, 3 nonsense, 3 frameshift, 1 splice site, and 2 alternatively spliced mutations had been reported in the NR3C1 gene to be associated with glucocorticoid resistance; 16 polymorphisms had also been reported.
Glucocorticoid Receptor - NR3C1 – Salimetrics
The glucocorticoid receptor, NR3C1, is part of the nuclear receptor subfamily, and acts as a receptor for glucocorticoids, most importantly cortisol. NR3C1 is in abundance throughout the body and helps regulate genes that control metabolism, cell differentiation, functions of the nervous and immune systems, and in maintaining homeostasis after ...
Nr3c1 MGI Mouse Gene Detail - MGI:95824 - nuclear receptor …
View mouse Nr3c1 Chr18:39543598-39652474 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
NR3C1 nuclear receptor subfamily 3 group C member 1
2024年5月20日 · Clinical resource with information about NR3C1, Genome-wide meta-analysis identifies new susceptibility loci for migraine., Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs., Glucocorticoid resistance, and available tests.
Epigenetics of traumatic stress: The association of NR3C1 ... - Nature
2023年1月19日 · This study aimed to investigate the relationship between methylation at the glucocorticoid receptor gene (NR3C1) and PTSD treatment success of evidence-based psychotherapy.
NR3C1 overexpression regulates the expression and alternative
2023年4月5日 · NR3C1-encoding glucocorticoid receptors have dual roles as RNA-binding protein and transcription factor. Recent studies revealed that NR3C1 might play an important role in the pathogenesis of PTSD (Post-traumatic stress disorder).
Glucocorticoid Receptor (NR3C1) Variants Associate with the …
Glucocorticoid receptor (NR3C1) polymorphisms associate with obesity, muscle strength, and cortisol sensitivity. We examined associations among four NR3C1 polymorphisms and the muscle response to resistance training (RT). European-American adults (n ...
Glucocorticoid Receptor Gene ( NR3C1 ) Expression in the …
This study aimed to compare the NR3C1 expression among cancer patients with major depressive disorder (cancer depression), cancer patients without major depressive disorder (cancer non-depression), and major depressive disorder patients without ...
Glucocorticoid receptor ( NR3C1 ) genetic polymorphisms and the ...
2023年2月12日 · The glucocorticoid receptor gene (NR3C1) encodes the receptor to which cortisol and other glucocorticoids bind. Steroids in either oral, intratympanic, or intravascular forms are the treatment of choice for sudden sensorineural hearing loss …
Nr3c1 nuclear receptor subfamily 3, group C, member 1
2025年2月18日 · NR3C1 overexpression regulates the expression and alternative splicing of inflammation-associated genes involved in PTSD. The mitochondrial Ahi1/GR participates the regulation on mtDNA copy numbers and brain ATP levels …
Glucocorticoid receptor gene (NR3C1) methylation processes as ... - PubMed
The NR3C1 gene codes for the glucocorticoid receptor, a key element involved in several steps of HPA axis modulation. In this review, we gather existing evidence linking NR3C1 methylation pattern with either ELS or psychopathology.
NR3C1 overexpression regulates the expression and alternative …
2023年4月5日 · NR3C1 encodes the glucocorticoid receptors (GRs), which play key roles in the hypothalamic–pituitaryadrenal (HPA) axis, mediating stress management as a transcription factor and an RNA-binding protein (Daskalakis et al., 2015, Timmermans et al., 2019).
NR3C1 (nuclear receptor subfamily 3, group C, member …
2015年2月1日 · NR3C1 gene encodes the human glucocorticoid receptor (hGR), which is a ligand-dependent transcription factor and activates transcription of glucocorticoid-responsive genes through binding directly to glucocorticoid response elements (GREs) in their promoter region, or modulating transcriptional activity of other transcription factors through pro...
Nr3c1 nuclear receptor subfamily 3, group C, member 1
2025年2月8日 · Results suggest that apelin-13 upregulates BDNF against chronic stress-induced depression-like phenotypes by ameliorating hypothalamus-pituitary-adrenal axis and hippocampal glucocorticoid receptor dysfunctions.