NLRX1 or NLR family member X1, short for nucleotide-binding oligomerization domain, leucine rich repeat containing X1 is a protein that in humans is encoded by the NLRX1 gene. [5] [6] It is also known as NOD-like receptor X1, NLR family, X1, NOD5, NOD9, and CLR11.3, and is a member of the NOD-like receptor family of pattern recognition receptors.

The Nod-like receptor NLRX1 has many diverse, multifaceted roles in innate immune system signaling, and cellular localization plays a key role in determining NLRX1's function. Localized on and within the mitochondria, NLRX1 interacts with a multitude of pathways.

2008年1月16日 · Here we describe human NLRX1, a highly conserved nucleotide-binding domain (NBD)- and leucine-rich-repeat (LRR)-containing family member (known as NLR) that localizes to the mitochondrial...

2024年12月25日 · NLRX1 (NLR Family Member X1) is a Protein Coding gene. Diseases associated with NLRX1 include Long Qt Syndrome and Histiocytic Sarcoma . Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and DDX58/IFIH1-mediated induction of interferon-alpha/beta .

2022年12月1日 · NLRX1 regulates systemic energy metabolism through its biological function in mitochondria, but the metabolic regulatory mechanism of NLRX1 is very complex and is considered to depend on the cell type, time, and signal.

NLRX1 is an underappreciated member of the NOD‐like receptor family. Functions in pathogen response are responsible for the regulation of multiple immune pathways. Emergence in disease highlights the potential in exploiting NLRX1 as a therapeutic target.

NLRX1 is the first reported NLR that specifically controls ROS production. The human genome database shows the existence of NLRX1, an uncharacterized NLR on the 11q23.3 locus that gives rise to a protein of 975 amino acids (accession no NP_078894).

2025年2月9日 · NLRX1 increases human retinal pigment epithelial autophagy and reduces H2O2-induced oxidative stress and inflammation by suppressing FUNDC1 phosphorylation and NLRP3 activation. The regulatory role of NLRX1 in innate immunity and human disease.

Recent evidence has suggested that NLRX1 controls mitophagy through the detection of a specific "danger signal", namely the defective import of proteins into mitochondria, or mitochondrial protein import stress (MPIS).

2008年1月31日 · Here we describe human NLRX1, a highly conserved nucleotide-binding domain (NBD)- and leucine-rich-repeat (LRR)-containing family member (known as NLR) that localizes to the mitochondrial outer membrane and interacts with MAVS.