NEDD8 is a protein that in humans is encoded by the NEDD8 gene. [5][6] (in Saccharomyces cerevisiae this protein is known as Rub1) This ubiquitin-like (UBL) protein becomes covalently conjugated to a limited number of cellular proteins, in a …

Inactivation of the Nedd8 conjugation pathway by a dominant negative mutant of the Nedd8-conjugating enzyme Nce1/Ubc12 blocks the ubiquitination and degradation of p27 in cell extracts. Consistent with a role in cell-cycle progression, Nedd8 is expressed in proliferating cells and is itself down-regulated upon cellular differentiation.

NEDD8 (neural-precursor-cell-expressed developmentally down-regulated 8) is a protein involved in the regulation of cell growth, viability and development. [2] It is found ubiquitously throughout all tissues and cell types, and it is essential for cell fitness. It translates to a small 8kDa protein.

2024年4月5日 · NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate through a...

Here, we review the NEDD8 pathway, its importance in cancer, and the therapeutic potential of NAE inhibition. Keywords: NEDD8, ubiquitin, cullin-RING ligase, DNA rereplication.

NEDD8 is a ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin RING ligases. Many non-cullin neddylation targets have been proposed in recent years. However, overexpression of exogenous NEDD8 can trigger NEDD8 ...

2024年12月25日 · NEDD8 (NEDD8 Ubiquitin Like Modifier) is a Protein Coding gene. Diseases associated with NEDD8 include Malignant Astrocytoma and Parkinson's Disease . Among its related pathways are Vesicle-mediated transport and Clathrin-mediated endocytosis .

2021年10月12日 · Here, the authors identify similarities and differences of ubiquitin and NEDD8 phosphorylation, showing that phosphorylated NEDD8 has a distinct interactome and regulates HSP70 proteins.

2018年10月22日 · Protein modification by the ubiquitin-like molecule NEDD8 increases upon proteotoxic stress and it is characterised by the formation of hybrid NEDD8/ubiquitin conjugates.

NEDD8 /RUB1 (NEDD8) is an 8 kDa protein that is closely related to ubiquitin. Just like ubiquitin, NEDD8 can be conjugated to proteins (neddylation). Unlike ubiquitin, however, NEDD8 does not form chains and does not target proteins for degradation [11].