In humans, NDRG1 gene is located on the long arm of chromosome 8 (8q24.22). The gene encodes a 3.0 kilobases (kb) messenger RNA (mRNA) composed of 394 amino acids. NDRG1 belong to the NDRG1 family consisting of four members - NDRG1, NDRG2, NDRG3 and NDRG4 - that share a 53-65 % homology.

2024年12月25日 · NDRG1 (N-Myc Downstream Regulated 1) is a Protein Coding gene. Diseases associated with NDRG1 include Charcot-Marie-Tooth Disease, Type 4D and Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive. Among its related pathways are Gene expression (Transcription) and TP53 Regulates Transcription of Cell Death Genes.

2022年12月23日 · NDRG-1 (N-myc downstream-regulated gene 1) is a member of NDRG family that plays essential roles in cell differentiation, proliferation, and stress responses. Although the expression of NDRG1 is regulated by fluid shear stress, its …

2020年10月7日 · N-myc downstream-regulated gene 1 (NDRG1) is an intracellular protein that is induced under a wide variety of stress and cell growth-regulatory conditions. NDRG1 is up-regulated by cell differentiation signals in various cancer cell …

NDRG1 is a member of the α/β hydrolase superfamily that resides in the cytoplasm and participates in the stress responses, hormone response, cell growth, and differentiation. Several studies have pointed to the importance of NDRG1 in the carcinogenesis.

2020年3月6日 · Kosuke Watari et al. show that N-myc downstream-regulated gene 1 (NDRG1) stimulates new blood vessel formation that is induced by VEGF-A, using Ndrg1 knockout mice.

2025年2月8日 · NDRG1 completely inhibits growth in anchorage-independent assays and in vivo supports a biological function as a tumor suppressor in pancreatic cancer. NDRG1 over-expression is associated with breast cancer. NDRG1 plays vital roles in tumor metastasis suppression and is frequently silenced in metastatic colon cancers.

NDRG1 is an oncogenic signaling disruptor that plays a key role in multiple cancers, including aggressive pancreatic tumors. Recent studies have indicated a role for NDRG1 in the inhibition of multiple tyrosine kinases, including EGFR, c-Met, HER2 and HER3, etc.

The N-myc downstream–regulated gene (NDRG) family consists of four members: NDRG1, NDRG2, NDRG3, and NDRG4. The name of this family originates from the first gene discovered, NDRG1, as this gene can be repressed by the c-myc and N-Myc proto-oncogenes.

NDRG1 Activity in Fat Depots Is Associated With Type 2 Diabetes and Impaired Incretin Profile in Patients With Morbid Obesity.