Myb genes are part of a large gene family of transcription factors found in animals and plants. In humans, it includes Myb proto-oncogene like 1 and Myb-related protein B in addition to MYB proper.

2024年12月25日 · MYB (MYB Proto-Oncogene, Transcription Factor) is a Protein Coding gene. Diseases associated with MYB include Adenoid Cystic Carcinoma and Angiocentric Glioma. Among its related pathways are Gene expression (Transcription) and ESR-mediated signaling.

2021年2月26日 · In humans, the MYB gene family is composed of three members: MYB, MYBL1 and MYBL2, encoding the transcription factors MYB, MYBL1, and MYBL2 (also known as c-MYB, A-MYB, and B-MYB),...

The MYB protein is a pivotal player in the cellular transcriptional network, influencing major important processes such as cell proliferation, differentiation, and apoptosis. Because of its role in oncogenesis, MYB is now a compelling target for therapeutic interventions in cancer research.

The MYB gene is a master regulator of hematopoietic system development and function and deregulated MYB expression in humans leads to a constellation of hematological and non-hematological malignancies.

1999年5月13日 · The myb gene family consists of three members, named A, B and c-myb which encode nuclear proteins that function as transcriptional transactivators.

Gene ID: 4602, updated on 8-Feb-2025. This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis.

2025年2月8日 · Title: MYB alternative promoter activity is increased in adenoid cystic carcinoma metastases and is associated with a specific gene expression signature. MYB/LINC00092 regulatory axis promotes the progression of papillary thyroid carcinoma.

1999年5月13日 · The myb gene family consists of three members, named A, B and c-myb which encode nuclear proteins that function as transcriptional transactivators. Proteins encoded by these three genes exhibit a tripartate structure with an N-terminal DNA-binding domain, a central transactivation domain and a C-ter …

2025年2月27日 · INTRODUCTION. The MYB family is a large and conserved transcription factor (TF) with multiple functions. Although MYBs were first identified in animals, named after an avian myeloblastosis protein (v-Myb) (Klempnauer et al., 1982), they substantially appeared in larger numbers in plants and form one of the largest TF families (Yuan et al., 2021). ...

The first MYB gene was identified as the ‘oncogene’ v-MYB from the avian myeloblastosis virus. This gene appears to have originated from a vertebrate gene and has three members- c-MYB, A-MYB and B-MYB. The first plant MYB gene identified was …

V-myb avian myeloblastosis viral oncogene homolog (MYB) is a gene that encodes a transcription factor protein that functions in both transcriptional activation and transcriptional repression. The protein also regulates hematopoiesis and tumorigenesis.

MYB is a master regulator and pioneer factor highly expressed in hematopoietic progenitor cells (HPCs) where it contributes to the reprogramming processes operating during hematopoietic development. MYB plays a complex role being involved in …

MYB gene amplification and overexpression have been observed in acute myeloid leukaemia (AML), non-Hodgkin lymphoma, colorectal cancer, and breast cancer 5,45–48. Fusion with partner genes is mainly observed in solid tumours, as discussed in detail in the following sections.

2025年2月8日 · MYB sustains hypoxic survival of pancreatic cancer cells by facilitating metabolic reprogramming. MYB insufficiency disrupts proteostasis in hematopoietic stem cells, leading to age-related neoplasia. MYB interacts with androgen receptor, sustains its ligand-independent activation and promotes castration resistance in prostate cancer.

MYB can be activated by overexpression or inappropriate expression, structural alteration and/or genomic rearrangements. MYB is clearly required in the bone marrow, colonic crypt and neurogenic...

2023年4月13日 · Natural variation in proteins controlling blood stem cell genes leads to imbalances that accumulate with age until malignant disease arises. MYB plays a key role in gene regulation throughout the hematopoietic hierarchy and is critical for the maintenance of normal hematopoietic stem cells (HSC).

MYB transcription factors are involved in plant development, secondary metabolism, hormone signal transduction, disease resistance and abiotic stress tolerance. A comparative analysis of MYB family genes in rice and Arabidopsis will help reveal the evolution and function of MYB genes in plants.

2021年2月26日 · In humans, the MYB gene family is composed of three members: MYB, MYBL1 and MYBL2, encoding the transcription factors MYB, MYBL1, and MYBL2 (also known as c-MYB, A-MYB, and B-MYB), respectively.

2024年3月12日 · The MYB protein is a pivotal player in the cellular transcriptional network, influencing major important processes such as cell proliferation, differentiation, and apoptosis. Because of its role in oncogenesis, MYB is now a compelling target for therapeutic interventions in cancer research.

17 小时之前 · The mouse Myb gene is controlled by a cluster of 5 distal enhancers located from − 36kb to − 109kb upstream of its transcriptional start site (TSS) 41,45 (Fig. 1A). All enhancers display the ...

MYB transcription factors represent one of the largest protein families in plants. MYB transcription factors are characterized by highly conserved N-terminal MYB DNA-binding domain (DBD) repeats (Rs). Each repeat contains approximately 52 …

5 天之前 · Thus, as a downstream target gene of MYB, the expression of retinoic acid inducible gene I (RIG-I) was downregulated, leading to the inhibition of NF-κB signaling and EC activation, which further alleviated sepsis-associated ALI. Taken together, these findings reveal a powerful integrative understanding of the molecular mechanisms by which XBJ ...