2024年12月25日 · MUC20 (Mucin 20, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC20 include Childhood Hepatocellular Carcinoma. Among its related pathways are O-linked glycosylation of mucins and Metabolism of proteins.

2025年1月4日 · MUC20 is a novel transmembrane mucin expressed by the human corneal and conjunctival epithelia, and suggest that differential expression of MUC20 during differentiation has a role in maintaining ocular surface homeostasis.

Intracellular MUC20 variant 2 maintains mitochondrial calcium homeostasis and enhances drug resistance in gastric cancer. Fu L, et al. Gastric Cancer, 2022 May. PMID 35166958. Lnc-MUC20-9 binds to ROCK1 and functions as a tumor suppressor in bladder cancer. Dai R, et al. J Cell Biochem, 2020 Oct. PMID 31898364.

2024年9月17日 · Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades.

MUC20 is a prognostic marker in Kidney renal clear cell carcinoma Cancer specificity i Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected.

MUC20 has been localized to chromosome 3q29 and contains five exons coding for a 76–78 kDa protein. Abundant expression of MUC20 mRNA was detected in the kidney but moderately in placenta, lung, prostate, liver, colon, esophagus, rectum , and middle ear .

2018年7月11日 · These findings suggest that MUC20 knockdown suppresses the malignant phenotypes of PDAC cells at least partially through the inhibition of the HGF/MET pathway and that MUC20 could act as a...

2014年12月6日 · Reduced expression of MUC20 led to increased phosphorylation and activation of c-MET, STAT3, and ERK-1/2. In addition, exposure of drug-naïve cells to the c-MET ligand HGF induced activation of this pathway and of the proteasome ChT-L activity, but reduced carfilzomib sensitivity.

2024年12月25日 · MUC20-OT1 (MUC20 Overlapping Transcript) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with MUC20-OT1 include Lung Non-Small Cell Carcinoma and Glioma Susceptibility 1.

2013年6月20日 · MUC20 overexpression could enhance migration and invasion abilities of CRC cells. Translation of its roles into clinical practice will need further investigation and additional test validation. Cumulatively, MUC20 may serve as an important predictor of recurrence and poor outcome for CRC patients.