Metastasis-associated protein MTA2 is a protein that in humans is encoded by the MTA2 gene. [5] [6] MTA2 is the second member of the MTA family of genes. [5] [7] [8] MTA2 protein localizes in the nucleus and is a component of the nucleosome remodeling and the deacetylation complex . …

2024年12月25日 · MTA2 (Metastasis Associated 1 Family Member 2) is a Protein Coding gene. Diseases associated with MTA2 include Cockayne Syndrome and Pancreatic Cancer. Among its related pathways are RNA Polymerase I Promoter Opening and PIP3 activates AKT signaling.

MTA2 is a member of the metastasis tumor associated family of transcriptional regulators and is a central component of the nucleosome remodeling and histone deacetylation complex. MTA2 acts as a central hub for cytoskeletal organization and transcription and provides a link between nuclear and cytoskeletal organization.

Metastatic associated proteins (MTA) are integrators of upstream regulatory signals with the ability to act as master coregulators for modifying gene transcriptional activity. The MTA family includes three genes and multiple alternatively spliced variants.

MTA2 knockdown impairs invasion and metastasis of gastric cancer cells. results reveal a novel post-translational regulation of MTA2 by the way of p300-dependent acetylation, which is important for tumor cells growth and migration and provides a potential target for …

MTA2, a member of the metastatic tumor-associated transcriptional regulator family, is a core component of the nucleosome remodeling and histone deacetylation complex . MTA2 is upregulated in human cancers and is associated with an aggressive phenotype, treatment resistance, and a poor prognosis in cancer patients .

2014年11月14日 · MTA2 acts as a central hub for cytoskeletal organization and transcription and provides a link between nuclear and cytoskeletal organization. We will focus on MTA2 in this chapter, especially its role in breast cancer metastasis.