Mesothelin, also known as MSLN, is a protein that in humans is encoded by the MSLN gene. [5] [6]

Apr 7, 2021 · Mesothelin (MSLN) represents an attractive molecule for targeted cancer therapies. To identify tumors that might benefit from such therapies, tissue microarrays including 15,050 …

The MSLN gene is located at 16p13.3 and encodes for the MSLN mRNA. The pre-pro-mesothelin consists of a signaling peptide at the N-terminus (yellow), mature MPF (blue), furin cleavage …

Dec 25, 2024 · Complete information for MSLN gene (Protein Coding), Mesothelin, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human …

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Mar 4, 2025 · Title: Effects of hsa-mir-145-5p on the Regulation of msln Expression in Colorectal Adenocarcinoma. Mesothelin Expression Is Not Associated with the Presence of Cancer Stem …

Dec 1, 2020 · Mesothelin (MSLN) is a lineage restricted cell surface protein expressed in about 30% of human cancers and high MSLN expression is associated with poor survival in several …

Aug 23, 2019 · Mesothelin (MSLN), a tumor-associated antigen broadly overexpressed on various malignant tumor cells, while its expression is generally limited to normal mesothelial cells, is …

Since its discovery in 1992, mesothelin (MSLN) has generated significant interest as a therapeutic target. A number of characteristics make it ideal for this purpose. First, it is not expressed on …

Mesothelin (MSLN) was discovered as a cell surface protein normally expressed by mesothelial cells lining the pleura, pericardium, and peritoneum . It is aberrantly expressed in a variety of …

Apr 30, 2024 · MSLN was a predictor of PDAC mortality, superior to conventional pathologic features as a prognostic marker [[12], [13], [14]]. Additionally, MSLN has been shown to …

Nov 12, 2020 · Lentivirally transduced anti-MSLN CD3ζ/CD28/TLR2 CAR-T cells were found to have superior killing capacity of MSLN-expressing human lung cancer cells compared to …

Jan 27, 2025 · MSLN is a cell surface protein expressed in several cancer types, including mesothelioma (MESO), colorectal (CRC), non-small cell lung (NSCLC), ovarian (OVCA), and …

Introduction: Mesothelin (MSLN) is a tumor differentiation antigen normally restricted to the body's mesothelial surfaces, but significantly overexpressed in a broad range of solid tumors. For this …

Mar 26, 2021 · MSLN-CAR decreased the growth of MSLN-positive tumors concomitant with significantly increased T cells and cytokine levels compared to the control group. These results …

Jul 20, 2021 · Targeting of human MSLN + aPFs with two anti-MSLN immunotoxins killed fibroblasts engineered to express human mesothelin and reduced collagen deposition in livers …

Aug 8, 2024 · Mesothelin (MSLN) is a cell-surface glycoprotein expressed at low levels on normal mesothelium but overexpressed in many cancers. Mesothelin has been implicated to play …

Jul 18, 2024 · Mesothelin (MSLN) is a molecule expressed on the surface of various solid malignant tumor cells that is suitable as a target of tumor cells with high MSLN expression for …

Feb 18, 2019 · Mesothelin (MSLN) has been reported to be expressed in GC tissue and could be targeted by chimeric antigen receptor (CAR) T cells. Mesothelin targeting CAR-T has been …

Mesothelin (Msln) expression is increased in tissue fibroblasts of damaged liver and other organs and Msln is a common mediator of liver, lung, and kidney fibrosis. We show that anti-Msln …