Jan 21, 2011 · The MRE11 complex, consisting of meiotic recombination 11 (MRE11), RAD50 and Nijmegen breakage syndrome 1 (NBS1; also known as nibrin), is of key importance in the …

Dec 25, 2024 · MRE11 (MRE11 Homolog, Double Strand Break Repair Nuclease) is a Protein Coding gene. Diseases associated with MRE11 include Ataxia-Telangiectasia-Like Disorder 1 …

Jan 10, 2024 · Here we report that the DNA double-strand break sensor MRE11 suppresses mammary tumorigenesis through a pivotal role in regulating cGAS activation.

Mre11 stabilizes Nbs1 and Rad50 and MRN activates Chk2 downstream from ATM in response to replication-mediated DNA double strand breaks; MRE11 is a new common target in the …

Jul 26, 2009 · The Mre11 protein has well-documented functions in the repair of DNA double-strand breaks via homologous recombination. Now, several new studies reveal that Mre11 …

Dec 20, 2023 · Herein, we demonstrate that MRE11, a crucial homologous recombination (HR) protein, is lactylated at K673 by the CBP acetyltransferase in response to DNA damage and …

Aug 28, 2021 · MRE11, the core of the MRE11/RAD50/NBS1 complex, is one of key DNA damage response proteins. Increasing evidence suggests that its expression in cancer cells is …

Mutation of the Saccharomyces cerevisiae RAD52 (600392) epistasis group gene, MRE11, blocks meiotic recombination, confers profound sensitivity to double-strand break damage, and has a …

Feb 9, 2025 · Clinical resource with information about MRE11, Ataxia-telangiectasia-like disorder 1, and available tests. There are links to practice guidelines and authoritative resources like …

The missense mutation of conserved Proline residue in the nuclease domain of S. cerevisiae mre11 (mre11-P162S) results in DSBs forming a blockage, defective meiotic recombination, …