MRE11A - Wikipedia
Double-strand break repair protein MRE11 (Meiotic recombination 11) is an enzyme that in humans is encoded by the MRE11 gene. [5] The gene has been designated MRE11A to …
The MRE11 complex: starting from the ends - Nature
2011年1月21日 · The MRE11 complex, consisting of meiotic recombination 11 (MRE11), RAD50 and Nijmegen breakage syndrome 1 (NBS1; also known as nibrin), is of key importance in the …
MRE11 Gene - GeneCards | MRE11 Protein | MRE11 Antibody
2024年12月25日 · MRE11 (MRE11 Homolog, Double Strand Break Repair Nuclease) is a Protein Coding gene. Diseases associated with MRE11 include Ataxia-Telangiectasia-Like Disorder 1 …
MRE11 liberates cGAS from nucleosome sequestration during
2024年1月10日 · Here we report that the DNA double-strand break sensor MRE11 suppresses mammary tumorigenesis through a pivotal role in regulating cGAS activation.
MRE11 MRE11 homolog, double strand break repair nuclease
Mre11 stabilizes Nbs1 and Rad50 and MRN activates Chk2 downstream from ATM in response to replication-mediated DNA double strand breaks; MRE11 is a new common target in the …
Mre11: roles in DNA repair beyond homologous recombination
2009年7月26日 · The Mre11 protein has well-documented functions in the repair of DNA double-strand breaks via homologous recombination. Now, several new studies reveal that Mre11 …
Metabolic regulation of homologous recombination repair by MRE11 …
Herein, we demonstrate that MRE11, a crucial homologous recombination (HR) protein, is lactylated at K673 by the CBP acetyltransferase in response to DNA damage and dependent …
Post-Translational Modification of MRE11: Its Implication in DDR …
The missense mutation of conserved Proline residue in the nuclease domain of S. cerevisiae mre11 (mre11-P162S) results in DSBs forming a blockage, defective meiotic recombination, …
MRE11 HOMOLOG, DOUBLE-STRAND BREAK REPAIR NUCLEASE; MRE11 …
Mutation of the Saccharomyces cerevisiae RAD52 (600392) epistasis group gene, MRE11, blocks meiotic recombination, confers profound sensitivity to double-strand break damage, and has a …
Functions of the MRE11 complex in the development and …
The MRE11 complex (MRE11, RAD50, and NBS1) is a central component of the DNA damage response, governing both double-strand break repair and DNA damage response signaling. To …