2024年12月25日 · MGAT3 (Beta-1,4-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase) is a Protein Coding gene. Diseases associated with MGAT3 include Hepatoblastoma and Hepatocellular Carcinoma. Among its related pathways are N-glycan antennae elongation in the medial/trans-Golgi and Transport to the …

大鼠 MGAT3 在人胚胎肾 293 (HEK293) 细胞中的表达导致形成 36 kDa 蛋白，该蛋白显示显着的 MGAT 但不显示 DGAT 活性。 通过实时PCR分析对大鼠MGAT3的组织表达分析表明大鼠MGAT3在肠和胰腺中具有高水平表达。 因此，我们的结果为理解 MGAT2 和 MGAT3 的相对功能作用以及未来在动物模型中探索 MGAT3 功能提供了分子基础。 甘油三酯 (TAG) 吸收涉及其初始水解为脂肪酸和单酰基甘油 (MAG)，然后在肠细胞内重新合成为二酰基甘油 (DAG) 和 TAG。 …

平分型 N-乙酰葡萄糖胺 (bisecting GlcNAc)是由β1,4-N-乙酰氨基葡萄糖转移酶III (MAGT3)催化，将GlcNAc以β1,4-糖苷键连接到核心五糖中的甘露糖残基上形成的特殊糖链结构。 该研究发现，MDS / AML患者的骨髓基质细胞中bisecting GlcNAc表达显著下调。...

Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT3 gene. [5] [6] There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides.

2022年3月23日 · Our data demonstrated that the MGAT pathway has a role in hepatic lipid metabolism with MGAT2, more so than MGAT3, contributing to TG synthesis and secretion. The liver plays a central role in...

MGAT3 and MGAT5 competitively modified E-cadherin N-glycans. An N-glycosylation site on the beta-propeller domain of the integrin alpha5 subunit plays key roles in both its function and site-specific modification by beta1,4-N-acetylglucosaminyltransferase III.

本项目通过研究mgat3催化的平分型n-糖链对mds细胞增殖的影响，探索mgat3基因表达调控的分子机理，以及mgat3和平分型n-糖链表达与mds发展程度的相关性，以理解平分型n-糖链在骨髓造血微环境中的作用，并为mds的临床诊断和治疗提供科学依据。

2024年10月28日 · Clinical resource with information about MGAT3, Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers., and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

2020年3月19日 · We demonstrate a rigorous top-down approach using TCGA-based RNA-Seq analysis, multi-step validation using RT-qPCR, immunoblots and immunohistochemistry. We identified six unique glycoTs (B3GNT3,...

Acyl-coenzyme A:monoacylglycerol acyltransferase 3 (MGAT3) is a member of the MGAT family of enzymes that catalyze the synthesis of diacylglycerol (DAG) from monoacylglycerol (MAG), a committed step in dietary fat absorption.