May 9, 2004 · The basic helix-loop-helix (bHLH) gene Ascl1 (also known as Mash1) is coexpressed with Nkx2-2 in the neuroepithelial domain of the hindbrain, which gives rise to 5-HT neurons.

Jun 5, 2013 · Ascl1/Mash1 is a proneural transcription factor previously implicated in embryonic oligodendrogenesis and operating in genetic interaction with Olig2, an essential transcriptional regulator in oligodendrocyte development.

Progenitors in the telencephalic subventricular zone (SVZ) remain mitotically active throughout life, and produce different cell types at embryonic, postnatal and adult stages. Here we show that Mash1, an important proneural gene in the embryonic ...

Transcription Factor Mash1 is a key factor involved in direct lineage conversion into neurons, along with other transcription factors like Ascl1, Brn2, and Myt1L. It plays a crucial role in neuronal lineage determination during development and is utilized to derive various subtypes of neurons.

Apr 18, 2007 · Using Mash1 null mutant mice, we show that Mash1 is required for the generation of an early population of OPCs in the ventral forebrain between embryonic day 11.5 (E11.5) and E13.5, whereas OPCs generated later in embryonic development are not affected.

Ascl1 (previously Mash1) is a bHLH transcription factor essential for neuronal differentiation and specification in the nervous system. Although it has been studied for its role in several neural lineages, the full complement of lineages arising from Ascl1 progenitor cells remains unknown.

MASH1 is a useful adjunct marker for differentiating small cell carcinoma of the lung from Merkel cell carcinoma. Merkel cell carcinoma is the cutaneous counterpart of small cell carcinoma, and the most important differential diagnosis is cutaneous metastasis of …

Mar 31, 2011 · Ascl1 (Mash1) is a bHLH transcription factor essential for neural differentiation during embryogenesis but its role in adult neurogenesis is less clear.

Feb 8, 2025 · MASH1 is a useful adjunct marker for differentiating small cell carcinoma of the lung from Merkel cell carcinoma. Tumor marker mASH1 was highly (sensitivity of 71%) and specifically (specificity of 95%) expressed in poorly differentiated neuroendocrine carcinoma.

Mash1 is a basic helix-loop-helix (bHLH) transcription factor, which has an important role in Notch signaling and the differentiation of GABAergic neurons [18, 19]. The Notch signaling pathway controls the fate-choice decision by stem cells, including MSCs.