MAPK7 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.

2024年12月25日 · MAPK7 (Mitogen-Activated Protein Kinase 7) is a Protein Coding gene. Diseases associated with MAPK7 include Scoliosis, Isolated 1 and Multiple Endocrine Neoplasia, Type Iia. Among its related pathways are Toll Like Receptor 7/8 …

2025年2月26日 · MAPK7 (Mitogen-activated protein kinase 7), a member of MAPK family, controls cell differentiation, proliferation and survival. However, the specific role of Mapk7 in regulating...

MAPK7 is a target gene of miR-143a-3p in 3T3-L1 cells. Data show that ERK5 is consistently expressed and active in human melanoma tissues. Inhibition of ERK5 pathway drastically reduce the growth of melanoma cells and xenografts harboring wild-type (wt) or mutated BRAF.

MAPK7 (ERK5). Originally called Big MAP kinase or BMK1 because of its C-terminal domain that gives rise to a protein twice the size of ERK1/2. It is activated in a complex composed of MAP2K2 and MAP3K2, kinases that normally operate in the “p38 pathway.”

2025年1月4日 · MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5).

2024年8月16日 · FUNCTION: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C.

2015年6月4日 · MAPK7/ERK5 (extracellular-signal-regulated kinase 5) functions within a canonical three-tiered MAPK (mitogen activated protein kinase) signaling cascade comprising MEK (MAPK/ERK kinase) 5, MEKK (MEK kinase) 2/3 and ERK5 itself.

2010年2月1日 · Human ERK5 (MAPK7) is a Ser/Thr protein kinase of 816 amino-acids with a predicted mass of 98 kDa. The ERK5 N-terminus domain resembles the typical MAPK catalytic domain and includes the MAPK-conserved TXY activation sequence (T 218 EY 220 ) …

The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation.