2023年7月17日 · What does a MUTYH mutation mean for my blood relatives? If you have a mutation in 1 of your MUTYH genes, your biological parents, siblings, and children each have a 50% chance of having the same mutation. Your distant family members may also be at risk for having the same mutation.

MUTYH-associated polyposis (MAP) is a rare, hereditary (inherited) condition that causes polyps (abnormal tissue growths) in parts of your body. Polyps aren’t cancer, but some can turn into cancer if they aren’t removed.

MUTYH (mutY DNA glycosylase) is a human gene that encodes a DNA glycosylase, MUTYH glycosylase. It is involved in oxidative DNA damage repair and is part of the base excision repair pathway.

2024年9月16日 · MUTYH- associated polyposis is an autosomal recessive polyposis syndrome. Affected patients have multiple colorectal adenomas and an increased risk for developing colorectal cancer. This topic will review the clinical manifestations, diagnosis, and management of MUTYH- associated polyposis.

2024年12月25日 · MUTYH (MutY DNA Glycosylase) is a Protein Coding gene. Diseases associated with MUTYH include Familial Adenomatous Polyposis 2 and Gastric Cancer. Among its related pathways are Packaging Of Telomere Ends and Base excision repair.

The MUTYH gene provides instructions for making an enzyme called MYH glycosylase, which is involved in the repair of DNA. This enzyme corrects particular errors that are made when DNA is copied (DNA replication) in preparation for cell division.

2012年10月4日 · MUTYH polyposis (also referred to as MUTYH-associated polyposis, or MAP) is characterized by a greatly increased lifetime risk of colorectal cancer (CRC). Although typically associated with ten to a few hundred colonic adenomatous polyps, CRC develops in some individuals in the absence of polyposis.

If you carry a MUTYH mutation, you may be at elevated risk for colon cancer. Find out what you need to know about the risks associated with MUTYH and how you can prevent them.

2024年8月30日 · People with an inherited mutation in both copies of their MUTYH gene have an increased risk for certain types of cancer. Read more about these risks. FORCE is here to guide you.

2020年7月24日 · This review evaluates the role of MUTYH, focusing on current studies of human neoplastic and non-neoplastic diseases different to colon polyposis and colorectal cancer. This will provide novel insights into the understanding of the molecular basis underlying MUTYH-related pathogenesis.