
MT2A Gene - GeneCards | MT2 Protein | MT2 Antibody
2024年12月25日 · MT2A (Metallothionein 2A) is a Protein Coding gene. Diseases associated with MT2A include Scrapie and Immunodeficiency 48 . Among its related pathways are Metal ion SLC transporters and Antiviral mechanism by IFN-stimulated genes .
Metallothionein 2A - Wikipedia
Metallothionein-2 is a metallothionein protein that in humans is encoded by the MT2A gene. [3] [4] The single-nucleotide polymorphism rs28366003 which substitutes guanine for adenine in MT2A is associated with certain cancers and some chronic diseases. [5]
MT2A is an early predictive biomarker of response to ... - Nature
2019年8月23日 · Our results show that MT2A level could be used as a predictive biomarker of resistance to chemotherapy, and provide with preclinical rational for MT2A targeting as a therapeutic strategy for...
MT2A protein expression summary - The Human Protein Atlas
MT2A is a prognostic marker in Glioblastoma multiforme, Head and neck squamous cell carcinoma, Kidney renal clear cell carcinoma, Liver hepatocellular carcinoma, Lung squamous cell carcinoma, Pancreatic adenocarcinoma
Metallothionein 2A (MT2A) controls cell proliferation and liver ...
The expression level of metallothionein 2A (MT2A), also known as MT2, is associated with tumor types. For example, MT2A is downregulated in gastric cancer and is related to the chemotherapy sensitivity of gastric cancer cells to docetaxel . Moreover, MT2A exerts its anti-gastric cancer effect by combining with MZF1 to target NFKBIA .
4502 - Gene ResultMT2A metallothionein 2A [ (human)]
MT2A Promotes Oxaliplatin Resistance in Colorectal Cancer Cells. Expression profiles of metallothionein-I/II and megalin/LRP-2 in uterine cervical squamous lesions. MT2A is an early predictive biomarker of response to chemotherapy and a …
MT2A promotes angiogenesis in chronically ischemic brains …
2025年2月6日 · Metallothionein 2 A (MT2A) has a high affinity for metal ions and is potentially capable of chelating toxic copper ions to alleviate the impairment of angiogenesis. Therefore, we hypothesized that MT2A could promote angiogenesis in chronically ischemic brains by neutralizing excessive copper ions during copper overload (CPO).
MT2A metallothionein 2A [ Homo sapiens (human) ] - National …
2025年1月4日 · Title: ptk2 and mt2a Genes Expression in Gastritis and Gastric Cancer Patients with Helicobacter pylori Infection. Downregulation of metallothionein 2A reduces migration, invasion and proliferation activities in human squamous cell carcinoma cells.
Mammalian Metallothionein-2A and Oxidative Stress - PMC
Mammalian metallothionein-2A (MT2A) has received considerable attention in recent years due to its crucial pathophysiological role in anti-oxidant, anti-apoptosis, detoxification and anti-inflammation.
HMBOX1 interacts with MT2A to regulate autophagy and apoptosis in ...
2015年10月12日 · Metallothionein 2A (MT2A) was identified as an interaction protein with HMBOX1 by yeast two-hybrid assay and confirmed by co-immunoprecipitation. Overexpression of HMBOX1 elevated intracellular...
Effect of MT2A on apoptosis and proliferation in HL60 cells
Therefore, we detected the effects of MT2A gene over-expression or down-expression on HL60 cell proliferation and apoptosis and the related molecular mechanisms, to explore the possibility of MT2A as a therapeutic target biomarker for AML.
Metallothionein 2A with Antioxidant and Antitumor Activity Is ...
2022年8月1日 · Functions of metallothionein 2A (MT2A) in bladder cancer have not been extensively explored even though metallothioneins are regarded as modulators in several biological regulations including oxidation and cancerous development. We evaluated MT2A in bladder carcinoma cells in terms of the mechanisms of regulation and the underlying functions.
Mammalian Metallothionein-2A and Oxidative Stress - PubMed
2016年9月6日 · Mammalian metallothionein-2A (MT2A) has received considerable attention in recent years due to its crucial pathophysiological role in anti-oxidant, anti-apoptosis, detoxification and anti-inflammation.
Metallothionein 2A (MT2A) controls cell proliferation and liver ...
2022年5月31日 · Metallothionein 2A (MT2A) was downregulated in the tumor tissues of patients with CRC compared to adjacent normal tissues and was related to the tumor M stage of patients. MT2A overexpression inhibited CRC cell proliferation and migration in cells, as well as growth and metastasis in CRC animal models.
MT2A promotes angiogenesis in chronically ischemic brains …
2025年2月6日 · MT2A alleviates the inhibitory effect of CPO on cerebral angiogenesis in 2VO + EMS rats. To prove the ability of MT2A to neutralize CPO and promote angiogenesis, we performed intraventricular lentivirus injection, and successful transfection was confirmed by WB and qPCR (Fig. 10A-C).
Metallothionein 2A inhibits NF-κB pathway activation and predicts ...
2013年7月19日 · Metallothionein 2A (MT2A) as a stress protein, plays a protective role in gastric mucosal barrier. Its role in the development of gastric cancer (GC) is unclear. The mechanism of MT2A will be investigated in gastric tumorigenesis. MT2A expression was detected in …
Mammalian Metallothionein-2A and Oxidative Stress - MDPI
2016年9月6日 · Mammalian metallothionein-2A (MT2A) has received considerable attention in recent years due to its crucial pathophysiological role in anti-oxidant, anti-apoptosis, detoxification and anti-inflammation.
Pharos : Target Details - MT2A - National Institutes of Health
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. This gene is a member of the metallothionein family of genes.
MT2A is an early predictive biomarker of response to …
Our results show that MT2A level could be used as a predictive biomarker of resistance to chemotherapy, and provide with preclinical rational for MT2A targeting as a therapeutic strategy for enhancing anti-tumour treatment of innate chemo-resistant osteosarcoma cells.
Molecular Mechanisms of Host Resistance to Biotrophs
R-genes of Arabidopsis are mapped on five chromosomes in MRC-A, MRC-B, MRC-F, MRC-H, and MRC-J as RPP1 to RPP27. Single transduction pathways used by the different RPP genes are complex and diverse. Stable and transient gene silencing approaches have been applied in downy mildew of crucifers.