2024年12月25日 · MT2A (Metallothionein 2A) is a Protein Coding gene. Diseases associated with MT2A include Scrapie and Immunodeficiency 48 . Among its related pathways are Metal ion SLC transporters and Antiviral mechanism by IFN-stimulated genes .

Metallothionein-2 is a metallothionein protein that in humans is encoded by the MT2A gene. [3] [4] The single-nucleotide polymorphism rs28366003 which substitutes guanine for adenine in MT2A is associated with certain cancers and some chronic diseases. [5]

2019年8月23日 · Our results show that MT2A level could be used as a predictive biomarker of resistance to chemotherapy, and provide with preclinical rational for MT2A targeting as a therapeutic strategy for...

MT2A is a prognostic marker in Glioblastoma multiforme, Head and neck squamous cell carcinoma, Kidney renal clear cell carcinoma, Liver hepatocellular carcinoma, Lung squamous cell carcinoma, Pancreatic adenocarcinoma

The expression level of metallothionein 2A (MT2A), also known as MT2, is associated with tumor types. For example, MT2A is downregulated in gastric cancer and is related to the chemotherapy sensitivity of gastric cancer cells to docetaxel . Moreover, MT2A exerts its anti-gastric cancer effect by combining with MZF1 to target NFKBIA .

MT2A Promotes Oxaliplatin Resistance in Colorectal Cancer Cells. Expression profiles of metallothionein-I/II and megalin/LRP-2 in uterine cervical squamous lesions. MT2A is an early predictive biomarker of response to chemotherapy and a …

2025年2月6日 · Metallothionein 2 A (MT2A) has a high affinity for metal ions and is potentially capable of chelating toxic copper ions to alleviate the impairment of angiogenesis. Therefore, we hypothesized that MT2A could promote angiogenesis in chronically ischemic brains by neutralizing excessive copper ions during copper overload (CPO).

2025年1月4日 · Title: ptk2 and mt2a Genes Expression in Gastritis and Gastric Cancer Patients with Helicobacter pylori Infection. Downregulation of metallothionein 2A reduces migration, invasion and proliferation activities in human squamous cell carcinoma cells.

Mammalian metallothionein-2A (MT2A) has received considerable attention in recent years due to its crucial pathophysiological role in anti-oxidant, anti-apoptosis, detoxification and anti-inflammation.

2015年10月12日 · Metallothionein 2A (MT2A) was identified as an interaction protein with HMBOX1 by yeast two-hybrid assay and confirmed by co-immunoprecipitation. Overexpression of HMBOX1 elevated intracellular...

Therefore, we detected the effects of MT2A gene over-expression or down-expression on HL60 cell proliferation and apoptosis and the related molecular mechanisms, to explore the possibility of MT2A as a therapeutic target biomarker for AML.

2022年8月1日 · Functions of metallothionein 2A (MT2A) in bladder cancer have not been extensively explored even though metallothioneins are regarded as modulators in several biological regulations including oxidation and cancerous development. We evaluated MT2A in bladder carcinoma cells in terms of the mechanisms of regulation and the underlying functions.

2016年9月6日 · Mammalian metallothionein-2A (MT2A) has received considerable attention in recent years due to its crucial pathophysiological role in anti-oxidant, anti-apoptosis, detoxification and anti-inflammation.

2022年5月31日 · Metallothionein 2A (MT2A) was downregulated in the tumor tissues of patients with CRC compared to adjacent normal tissues and was related to the tumor M stage of patients. MT2A overexpression inhibited CRC cell proliferation and migration in cells, as well as growth and metastasis in CRC animal models.

2025年2月6日 · MT2A alleviates the inhibitory effect of CPO on cerebral angiogenesis in 2VO + EMS rats. To prove the ability of MT2A to neutralize CPO and promote angiogenesis, we performed intraventricular lentivirus injection, and successful transfection was confirmed by WB and qPCR (Fig. 10A-C).

2013年7月19日 · Metallothionein 2A (MT2A) as a stress protein, plays a protective role in gastric mucosal barrier. Its role in the development of gastric cancer (GC) is unclear. The mechanism of MT2A will be investigated in gastric tumorigenesis. MT2A expression was detected in …

2016年9月6日 · Mammalian metallothionein-2A (MT2A) has received considerable attention in recent years due to its crucial pathophysiological role in anti-oxidant, anti-apoptosis, detoxification and anti-inflammation.

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. This gene is a member of the metallothionein family of genes.

Our results show that MT2A level could be used as a predictive biomarker of resistance to chemotherapy, and provide with preclinical rational for MT2A targeting as a therapeutic strategy for enhancing anti-tumour treatment of innate chemo-resistant osteosarcoma cells.

R-genes of Arabidopsis are mapped on five chromosomes in MRC-A, MRC-B, MRC-F, MRC-H, and MRC-J as RPP1 to RPP27. Single transduction pathways used by the different RPP genes are complex and diverse. Stable and transient gene silencing approaches have been applied in downy mildew of crucifers.