Dec 25, 2024 · MSR1 (Macrophage Scavenger Receptor 1) is a Protein Coding gene. Diseases associated with MSR1 include Barrett Esophagus and Metabolic Dysfunction-Associated Steatotic Liver Disease. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Vesicle-mediated transport.

该基因编码 A 类巨噬细胞清道夫受体，包括通过该基因的选择性剪接产生的三种不同类型 (1、2、3) 。 这些受体或同种型是巨噬细胞特异性三聚体整合膜糖蛋白，并且与许多巨噬细胞相关的生理和病理过程有关，包括动脉粥样硬化、阿尔茨海默氏病和宿主防御。 1 型和 2 型亚型是功能性受体，能够介导修饰的低密度脂蛋白 (LDL) 的内吞作用。 尽管在 1 型和 2 型亚型中显示出介导此功能的结构域，但 3 型亚型不会内化修饰的 LDL (乙酰基-LDL) 。 它具有改变的细胞内加工并被困 …

Macrophage scavenger receptor 1, also known as MSR1, is a protein which in humans is encoded by the MSR1 gene. [5][6] MSR1 has also been designated CD204 (cluster of differentiation 204). This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene.

SRA1.1是SR - A1的选择性剪接变体，其特征是羧基端较短。 SR - A1和SR - A1.1的 胶原结构域被认为是配体结合位点，因为它能够与 多阴离子配体相互作用。 SR - A3、SR - A4和SR - A5表达于不同器官，包括肺、心脏、胎盘、肠和上皮细胞，而 SR - A6主要表达于巨噬细胞。 与其他A类SR不同，它保护细胞免受活性氧的伤害。 脂蛋白的内皮受体，参与OxLDL的识别和降解，似乎是巨噬细胞SR - A1的内皮对应物。 表达仅限于气道、肾上腺和胸腺的上皮细胞。 与SRA1相 …

Oct 17, 2022 · Macrophage scavenger receptor 1 (MSR1), also named CD204, holds key inflammatory roles in multiple pathophysiologic processes. Present primarily on the surface of various types of macrophage, this receptor variably affects processes such as atherosclerosis, innate and adaptive immunity, lung and liv …

Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis. MSR1 characterized by chromatin accessibility mediates M2 macrophage polarization to promote gastric cancer progression. Comprehensive analysis of the prognostic and role in immune cell infiltration of MSR1 expression in lower-grade gliomas.

Herein, we show that the macrophage scavenger receptor MSR1, an innate immune receptor, mediates lipid uptake and accumulation in Kupffer cells, resulting in liver inflammation and thereby promoting the progression of NAFLD in humans and mice.

巨噬细胞清道夫受体 1 (msr1)，也称为 cd204，在多种病理生理过程中具有关键的炎症作用。 这种受体主要存在于各种类型的巨噬细胞表面，对动脉粥样硬化、先天性和适应性免疫、肺和肝病以及最近的癌症等过程产生不同程度的影响。

Jan 3, 2025 · Macrophage scavenger receptor 1 (MSR1), as a key receptor in macrophages, is essential in tumor immunity. However, its mechanisms in regulating tumor progression and immunity and its prognostic value in LUSC remain unclear.

Enables amyloid-beta binding activity; cargo receptor activity; and low-density lipoprotein particle binding activity. Involved in several processes, including endocytosis; positive regulation of Cholesterol storage; and positive regulation of macrophage derived foam cell differentiation. Acts upstream of or within lipoprotein transport.