Macrophage scavenger receptor 1, also known as MSR1, is a protein which in humans is encoded by the MSR1 gene. [5] [6] MSR1 has also been designated CD204 (cluster of differentiation 204).

2024年12月25日 · MSR1 (Macrophage Scavenger Receptor 1) is a Protein Coding gene. Diseases associated with MSR1 include Barrett Esophagus and Metabolic Dysfunction-Associated Steatotic Liver Disease. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Vesicle-mediated transport.

2022年10月17日 · Macrophage scavenger receptor 1 (MSR1), also named CD204, holds key inflammatory roles in multiple pathophysiologic processes. Present primarily on the surface of various types of macrophage, this receptor variably affects processes such as atherosclerosis, innate and adaptive immunity, lung and liv …

Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis. MSR1 characterized by chromatin accessibility mediates M2 macrophage polarization to promote gastric cancer progression. Comprehensive analysis of the prognostic and role in immune cell infiltration of MSR1 expression in lower-grade gliomas.

2022年10月16日 · Macrophage scavenger receptor 1 (MSR1), also named CD204, holds key inflammatory roles in multiple pathophysiologic processes. Present primarily on the surface of various types of macrophage, this receptor variably affects processes such as atherosclerosis, innate and adaptive immunity, lung and liver disease, and more recently, cancer.

Msr1, also known as scavenger receptor a1 (Scara1), is a type II transmembrane glycoprotein mainly expressed by microglia in CNS [16]. Msr1 has been involved in many macrophage-associated physiological and pathological conditions such as neurodegenerative diseases [17].

Herein, we show that the macrophage scavenger receptor MSR1, an innate immune receptor, mediates lipid uptake and accumulation in Kupffer cells, resulting in liver inflammation and thereby promoting the progression of NAFLD in humans and mice.

2025年2月4日 · Macrophage MSR1 promotes the formation of foamy macrophage and neuronal apoptosis after spinal cord injury. Scavenger receptor A impairs interferon response to HBV infection by limiting TRAF3 ubiquitination through recruiting OTUB1. Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis.

2023年11月23日 · Comprehensive analysis of immune cell infiltration and role of MSR1 expression in aneurysmal subarachnoid haemorrhage. MSR1 characterized by chromatin accessibility mediates M2 macrophage polarization to promote gastric cancer progression.

The MSR1 gene is located at 8p22 and functions in several processes proposed to be relevant to prostate carcinogenesis. In studies of families affected with hereditary prostate cancer, Xu et al. (2002) identified 6 missense mutations and 1 nonsense mutation in the MSR1 gene.