Multidrug resistance-associated protein 1 (MRP1) is a protein that in humans is encoded by the ABCC1 gene. [5][6] The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes.

2024年12月24日 · ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance.

ABCC1 or multidrug resistance-associated protein 1 (MRP1) is a unidirectional efflux transporter with ubiquitous tissue distribution and wide substrate specificity including important therapeutics.

2009年8月12日 · MRP1 acts as an ATP-dependent efflux pump for the transport of organic anions, glutathione-, glucuronate-, or sulfate-conjugated drugs, or unconjugated drugs in concert with free glutathione (1, 2), including the chemotherapeutic agents vincristine, doxorubicin, and …

2013年5月7日 · Although multidrug-resistance-associated protein-1 (MRP1) is a major contributor to multi-drug resistance (MDR), the regulatory mechanism of Mrp1 still remains unclear. Nrf2 is a transcription factor that regulates cellular defense response through antioxidant response elements (AREs) in normal tissues.

MRP1 is known for its ability to actively decrease intracellular drug concentration, limiting the efficacy of cancer chemotherapy; however, data on the clinical relevance of MRP1 is inconclusive.

2020年5月27日 · The conformational dynamics of multidrug resistance protein 1 (MRP1) are tracked in real time by single-molecule fluorescence resonance energy transfer experiments, which elucidate the rate-limiting mechanism of MRP1's transport cycle.

MRP1/ABCC1 (D5C1X) Rabbit mAb recognizes endogenous levels of total MRP1 protein. This antibody does not cross-react with MRP2 and MRP3 proteins. Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val273 of human MRP1 protein.

The multidrug resistance protein 1 (MRP1) encoded by ABCC1 was originally discovered as a cause of multidrug resistance in tumor cells. However, it is now clear that MRP1 serves a broader role than simply mediating the ATP-dependent efflux of drugs from cells.

2023年8月21日 · The Multidrug Resistance Protein 1 (Mrp1) is an ATP-dependent efflux transporter and a major facilitator of drug resistance in mammalian cells during cancer and HIV therapy. In brain, Mrp1-mediated GSH export from astrocytes is the first step in the supply of GSH precursors to neurons.