Matrilysin also known as matrix metalloproteinase-7 (MMP-7), pump-1 protease (PUMP-1), or uterine metalloproteinase is an enzyme in humans that is encoded by the MMP7 gene. [5]

High MMP-7 have been detected in premature babies and young infants with cardiovascular and/ or multi-system disease. The final diagnosis of biliary atresia requires intraoperative cholangiography and the histological presence of obstruction of the extrahepatic bile duct.

Nov 1, 2019 · Matrix metalloproteinase-7 (MMP-7) has been reported to be promising in diagnosing BA. We aimed to validate the diagnostic accuracy of MMP-7 for BA in a large population sample. We enrolled 288 patients with neonatal obstructive jaundice from March 2017 to October 2018. Serum MMP-7 levels were measured by using an enzyme-linked …

Matrix metalloproteinase-7 (MMP-7) is a small proteolytic enzyme that secretes zinc and calcium endopeptidases. It can degrade a variety of extracellular matrix substrates and other substrates and plays important regulatory roles in many human pathophysiological processes.

For the purpose of this review the detailed characteristics of MMP-2, MMP-7, and TIMP-2 (as the main inhibitor of MMP-2) are presented. According to the available data, MMP-2 and MMP-7 are among the most important metalloproteinases in the pathogenesis of tumor formation.

Matrix metalloproteinase-7 (MMP-7) is a secreted zinc-dependent endopeptidase that is implicated in regulating kidney homeostasis and diseases. MMP-7 is produced as an inactive zymogen, and proteolytic cleavage is required for its activation.

Dec 25, 2024 · MMP7 (Matrix Metallopeptidase 7) is a Protein Coding gene. Diseases associated with MMP7 include Biliary Atresia and Rectum Cancer. Among its related pathways are Collagen chain trimerization and Matrix metalloproteinases. Gene Ontology (GO) annotations related to this gene include peptidase activity and metallopeptidase activity.

Dec 10, 2024 · Title: Matrix Metalloproteinase-7 in Urinary Extracellular Vesicles Identifies Rapid Disease Progression in Autosomal Dominant Polycystic Kidney Disease. The magnetic resonance imaging and age-adjusted matrix metalloproteinase-7 assist the diagnosis of biliary atresia.

Feb 3, 2021 · We previously identified matrix metalloproteinase 7 (MMP7) as a serum biomarker of histological advanced fibrosis in a mixed-etiology patient cohort. In this study we aimed to determine the...

MMP-7, one of the best described biomarkers in IPF so far, is a member of the extensive MMP family, with the smallest molecular weight (247 amino acids). MMP-7 is expressed in alveolar macrophages and in alveolar and bronchiolar epithelial cells, and is known to degrade several ECM components.