Histone-lysine N-methyltransferase 2D (KMT2D), also known as MLL4 and sometimes MLL2 in humans and Mll4 in mice, is a major mammalian histone H3 lysine 4 (H3K4) mono-methyltransferase. [5] It is part of a family of six Set1-like H3K4 methyltransferases that also contains KMT2A (or MLL1), KMT2B (or MLL2), KMT2C (or MLL3), KMT2F (or SET1A), and ...

The Mixed Lineage Leukemia 2 (MLL2) protein, also known as KMT2B, belongs to the family of mammalian histone H3 lysine 4 (H3K4) methyltransferases. It is a large protein of 2715 amino acids, widely expressed in adult human tissues and a paralog of ...

2024年12月25日 · KMT2D (Lysine Methyltransferase 2D) is a Protein Coding gene. Diseases associated with KMT2D include Kabuki Syndrome 1 and Branchial Arch Abnormalities, Choanal Atresia, Athelia, Hearing Loss, And Hypothyroidism Syndrome. Among its related pathways are RNA Polymerase I Promoter Opening and Gene expression (Transcription).

Histone-lysine N-methyltransferase 2D (KMT2D), also known as MLL4 and MLL2 in humans and Mll4 in mice, belongs to a family of mammalian histone H3 lysine 4 (H3K4) methyltransferases. It is a large protein over 5,500 amino acids in size and is …

The KMT2D gene (also known as MLL2) encodes a member of the SET1 family of histone methyltransferases that facilitates transcription by predominantly mono- and di-methylating the lysine 4 of histone H3 (H3K4).

We show that Mll2 deletion reduced MLL-AF9 leukemia cell survival, and that the co-deletion of both Mll1 and Mll2 resulted in more severe reductions in survival, proliferation and gene expression than either individual gene deletion.

2017年9月5日 · Histone-lysine N-methyltransferase 2D (KMT2D), also known as MLL4 and MLL2 in humans and Mll4 in mice, belongs to a family of mammalian histone H3 lysine 4 (H3K4) methyltransferases. It is a large protein over 5500 amino acids in size and is partially functionally redundant with KMT2C.

MLL2 is a tumor suppressor gene encoding histone H3 lysine 4 (H3K4) mono-methyltransferase, that colocalizes with lineage determining transcription factors on transcriptional enhancers and is essential for cell differentiation and embryonic development.

2017年6月12日 · Mll2 deletion reduces the survival of MLL-AF9 leukemia, and Mll1 deletion in this context exacerbates this effect and reduces leukemogenesis in vivo. These data support the concept that targeting MLL2 itself would be a valuable therapeutic strategy.

2017年6月12日 · We show that MLL1/MLL2 collaboration is not through redundancy, but regulation of distinct pathways. These findings highlight the relevance of MLL2 as a drug target in MLL-rearranged leukemia and suggest its broader significance in AML.